2,2-Diethoxyethylamine Chemical Properties

Melting point:

-78

Boiling point:

162-163 °C (lit.)

Density 

0.916 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.417(lit.)

Flash point:

114 °F

storage temp. 

Keep in dark place,Inert atmosphere,2-8°C

solubility 

Chloroform (Slightly), Ethyl Acetate (Slightly)

pka

pK1:8.47(+1) (25°C)

form 

clear liquid

color 

Colorless to Light yellow

Water Solubility 

soluble

BRN 

506067

InChI

1S/C6H15NO2/c1-3-8-6(5-7)9-4-2/h6H,3-5,7H2,1-2H3

InChIKey

HJKLEAOXCZIMPI-UHFFFAOYSA-N

SMILES

CCOC(CN)OCC

CAS DataBase Reference

645-36-3(CAS DataBase Reference)

NIST Chemistry Reference

Ethanamine, 2,2-diethoxy-(645-36-3)

EPA Substance Registry System

Ethanamine, 2,2-diethoxy- (645-36-3)

Safety Information

Hazard Codes 

Xi,C,F

Risk Statements 

10-36/37/38-34

Safety Statements 

23-24/25-26-45-36/37/39-16-36

RIDADR 

UN 1989 3/PG 3

WGK Germany 

3

Hazard Note 

Irritant

TSCA 

TSCA listed

HazardClass 

3

PackingGroup 

III

HS Code 

29225090

Storage Class

3 - Flammable liquids

Hazard Classifications

Eye Dam. 1
Flam. Liq. 3
Skin Corr. 1B

MSDS

• Language:English Provider:2,2-Diethoxyethylamine
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

2,2-Diethoxyethylamine Usage And Synthesis

Chemical Properties

CLEAR COLOURLESS TO LIGHT YELLOW LIQUID

Uses

Aminoacetaldehyde diethyl acetal, is used as an agrochemical intermediate, pharmaceutical, syntheses material intermediate.

Synthesis

There are two main methods of synthesizing aminoacetaldehyde diethyl acetal as follows:

(1) 2-(2-azidoethyl)-1,3-dioxolane is generated from 2-(2-azidoethyl)-1,3-dioxolane by refluxing 2-(2-azidoethyl)-1,3-dioxolane with sodium azide over a phase transfer catalyst, which is further reacted with triphenylphosphine/water, but the NaN3 compounds are highly poisonous and explosive, which is not conducive to industrialized production.

(2) 2-(2-bromoethyl)-1,3-dioxolane is obtained by ion exchange with a macroporous quaternary ammonium Amberlite resin ( AmberliteIRA 900) that has been attached to a negative nitrite ion to obtain 2-(2-nitrosoethyl)-1,3-dioxolane, which is then catalyzed by platinum oxidation to obtain aminoglycolaldehyde diethyl acetal by platinum oxidation catalyst, which has a low yield.

2,2-Diethoxyethylamine(645-36-3)Related Product Information

• 1,1-Dimethoxyethane
• Bromoacetaldehyde dimethyl acetal
• Acrolein diethyl acetal
• Bromoacetaldehyde diethyl acetal
• Aminoacetaldehyde dimethyl acetal
• Diethyl phthalate
• 2-(4-Aminophenyl)ethanol
• 4,4-Diethoxybutylamine
• Chloroacetaldehyde diethyl acetal
• 2-(2-Aminothiazol-4-yl)glyoxylic acid
• Monoethanolamine
• 3,3-Diethoxypropionitrile
• Acetylacetaldehyde dimethyl acetal
• Acetal
• Diethyl malonate
• 2,6-DI-TERT-BUTYLNAPHTHALENE SULFONIC ACID SODIUM SALT
• Trimethylstearylammonium Chloride
• Benzyl carbamate