Bromocresol green Chemical Properties

Melting point:

225 °C (dec.) (lit.)

Density 

0.79 g/mL at 20 °C

bulk density

350kg/m3

Flash point:

12 °C

storage temp. 

no restrictions.

solubility 

Solubility Sparingly soluble in water; soluble in ethanol, ether, ethyl acetate

form 

Powder/Solid

pka

4.7(at 25℃)

Boiling point:

626.0±55.0 °C(Predicted)

color 

Pale orange

PH Range

3.8(YELLOW)-5.4(BLUE)

PH

3.8～5.4

Water Solubility 

slightly soluble

λmax

423nm, 444nm, 617nm

Merck 

14,1386

BRN 

372527

Stability:

Stable. Incompatible with strong oxidizing agents.

Major Application

Sol-gel matrix, fuel cells, sensors, display device, inks, paints, one-steptester for ammonia, cosmet-tester for ammonia, packaging system, textiles, cleansing products, detergents, cosmetics, diapers, identifying fresh and stale rice, monitoring fish spoilage, detecting carbohydrates, lacting acid bacteria, treating neoplasms, cancer, vaginal infection test method, drugs, dental materials

Cosmetics Ingredients Functions

COLORANT

InChI

1S/C21H14Br4O5S/c1-9-12(7-14(22)19(26)17(9)24)21(13-8-15(23)20(27)18(25)10(13)2)11-5-3-4-6-16(11)31(28,29)30-21/h3-8,26-27H,1-2H3

InChIKey

FRPHFZCDPYBUAU-UHFFFAOYSA-N

SMILES

Cc1c(Br)c(O)c(Br)cc1C2(OS(=O)(=O)c3ccccc23)c4cc(Br)c(O)c(Br)c4C

LogP

7.800 (est)

CAS DataBase Reference

76-60-8(CAS DataBase Reference)

EPA Substance Registry System

Bromcresol green (76-60-8)

Safety Information

Hazard Codes 

F,Xi,Xn

Risk Statements 

11-36-67-36/37/38-20/21/22

Safety Statements 

7-16-24/25-26-37/39-36

RIDADR 

UN 1219 3/PG 2

WGK Germany 

3

RTECS 

SJ7456000

Autoignition Temperature

399 °C

TSCA 

TSCA listed

HazardClass 

3

PackingGroup 

II

HS Code 

29349990

Storage Class

11 - Combustible Solids

MSDS

• Language:English Provider:Bromocresol green
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

Bromocresol green Usage And Synthesis

Chemical Properties

tan to yellow crystals

Uses

Bromocresol Green is a pH sensitive indicator used in the growth medium for microorganisms and titrations. It is useful in various colorimetric detection studies and as an actively tracking dye for DNA agarose gel electrophoresis. It acts as an inhibitor of prostaglandin E2 transport protein. It is also used in TLC for visualizing compounds containing functional groups having pKa less than 5.

Uses

Bromocresol Green (BCG) is a pH sensitive triphenylmethane dye useful in a variety of colorimetric detection technologies. BCG is used as a tracking dye for DNA agarose gel electrophoresis, in protein determinations and in charge-transfer complexation processes. In TLC BCG is used for visualisation of the compounds with functional groups whose pKa is below 5.0.

Uses

As indicator, pH 3.8 yellow; pH 5.4 blue-green.

Definition

ChEBI: Bromocresolgreen is a member of benzofurans.

Hazard

Moderately toxic.

Synthesis

A method of preparing bromocresol green in the following steps:

(1) 1.5 kg of bromine is dissolved in 1.25 liters of glacial acetic acid solution to obtain a bromine-glacial acetic acid mixture;

(2) 2 kg of pure m-cresol violet is dissolved in a solution of 2.5 liters of glacial acetic acid;

(3) The bromine-ice acetic acid mixture obtained in step (1) is slowly dripped into the solution in step (2) at a temperature not exceeding 80?? C. After addition, stirring is continued and kept at 80 to 90?? C. for 24 hours, and then filtered after cooling down, and the precipitate is washed twice with ice acetic acid, dried or pumped, and dried at 50 to 60?? C. to obtain the crude bromocresol green. Moreover, the crude bromocresol green was recrystallized with benzene or glacial acetic acid to obtain pure bromocresol green, which crystallized into white, melting point 218-9??C.

Purification Methods

Crystallise the dye from glacial acetic acid or dissolve it in aqueous 5% NaHCO3 solution and precipitate it from the hot solution by dropwise addition of aqueous HCl. Repeat this until the UV/VIS-extinction did not increase 423nm. It is an indicator: at pH 3.81 at max (yellow) and pH 5.4 (blue-green). [Beilstein 19/3 V 460.]

Bromocresol green(76-60-8)Related Product Information

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