2-Nitrofluorene Chemical Properties

Melting point:

156-158 °C (lit.)

Boiling point:

350.9°C (rough estimate)

Density 

1.1868 (rough estimate)

refractive index 

1.6060 (estimate)

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

form 

Powder

color 

White to brown

Water Solubility 

Insoluble

Stability:

Stable. Incompatible with strong oxidizing agents.

CAS DataBase Reference

607-57-8(CAS DataBase Reference)

NIST Chemistry Reference

Fluorene, 2-nitro-(607-57-8)

IARC

2B (Vol. 46, 105) 2014

EPA Substance Registry System

2-Nitrofluorene (607-57-8)

Safety Information

Hazard Codes 

Xn,N

Risk Statements 

40-51/53-68

Safety Statements 

36/37-61

RIDADR 

UN 3077 9/PG 3

WGK Germany 

3

RTECS 

LL8225000

TSCA 

Yes

HazardClass 

9

PackingGroup 

III

HS Code 

29042000

Hazardous Substances Data

607-57-8(Hazardous Substances Data)

MSDS

• Language:English Provider:2-Nitrofluorene
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS

2-Nitrofluorene Usage And Synthesis

Chemical Properties

cream powder

Uses

2-Nitrofluorene is a genotoxic compound and also a biomaker that affects the DNA of living organisms. An environmental pollutant.

Definition

ChEBI: A nitroarene that is fluorene substituted by a nitro group at position 2.

General Description

Cream-colored solid.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

Aromatic nitro compounds, such as 2-Nitrofluorene, range from slight to strong oxidizing agents. If mixed with reducing agents, including hydrides, sulfides and nitrides, they may begin a vigorous reaction that culminates in a detonation. The aromatic nitro compounds may explode in the presence of a base such as sodium hydroxide or potassium hydroxide even in the presence of water or organic solvents. The explosive tendencies of aromatic nitro compounds are increased by the presence of multiple nitro groups. Stable under normal conditions. Protect from bases.

Health Hazard

ACUTE/CHRONIC HAZARDS: Toxic. Hazardous decomposition products. Carcinogen.

Safety Profile

Confirmed carcinogen with experimental carcinogenic and tumorigenic data. Moderately toxic by intraperitoneal route. Human mutation data reported. When heated to decomposition it emits toxic fumes of NOx. See also NITRO COMPOUNDS OF AROMATIC HYDROCARBONS.

Metabolic pathway

Lung microsomal metabolism of 2-nitrofluorene (NF) increases in parallel with the accumulation of P-450b homologous mRNA and microsomal cytochrome P- 450b protein concentration. The formation of the major metabolite, and potent mutagen, 9-hydroxy-2- nitrofluorene (9-OHNF) is significantly inhibited by the addition of polyclonal anti-P-450b-IgG, and by the addition of the inhibitor, proadifen, to incubations with lung microsomal protein.

Purification Methods

Crystallise 2-nitrofluorene from aqueous acetic acid or Me2CO (m 158-158.5o, also 160-160.5o). [Beilstein 5 H 628, 5 III 1948.]

2-Nitrofluorene(607-57-8)Related Product Information

• 1-Phenyl-2-nitropropene
• 4-Nitrobenzoic acid
• 3-Nitroacetophenone
• Fluorene
• 9-DICYANOMETHYLENE-2,4,7-TRINITROFLUORENE
• Nitrobenzene
• 2,4,7-TRINITRO-9-FLUORENONE
• Nitromethane
• NITROGEN DIOXIDE
• 2,4,6-Trinitrotoluene
• 2,5-DINITROFLUORENE
• 2,4,5,7-TETRANITRO-9-FLUORENONE
• 2-NITROFLUORENE-9-ONE
• 2,7-Dinitro-9-fluorenone
• 2,7-Dinitrofluorene
• Nitroethane
• 4-Nitrophenol
• 2-CHLORO-7-NITROFLUORENE