Basic information Safety Supplier Related

Mal-PEG5-CH2CH2Mal

Basic information Safety Supplier Related

Mal-PEG5-CH2CH2Mal Basic information

Product Name:
Mal-PEG5-CH2CH2Mal
Synonyms:
  • Mal-PEG5-CH2CH2Mal
  • 1H-Pyrrole-2,5-dione, 1,1'-(3,6,9,12,15-pentaoxaheptadecane-1,17-diyl)bis-
CAS:
113387-03-4
MF:
C20H28N2O9
MW:
440.44
Mol File:
113387-03-4.mol
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Mal-PEG5-CH2CH2Mal Usage And Synthesis

Biological Activity

Mal-PEG5-mal is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

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