Mal-PEG5-CH2CH2Mal CAS#: 113387-03-4

Mal-PEG5-CH2CH2Mal Basic information

Product Name:

Mal-PEG5-CH2CH2Mal

Synonyms:

Mal-PEG5-CH2CH2Mal
1H-Pyrrole-2,5-dione, 1,1'-(3,6,9,12,15-pentaoxaheptadecane-1,17-diyl)bis-

CAS:

113387-03-4

MF:

C20H28N2O9

MW:

440.44

Mol File:

113387-03-4.mol

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Mal-PEG5-CH2CH2Mal Usage And Synthesis

Biological Activity

Mal-PEG5-mal is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

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