MICROCYSTIN-LR Chemical Properties

Density 

1.29±0.1 g/cm3(Predicted)

Flash point:

11 °C

storage temp. 

−20°C

solubility 

ethanol: 1 mg/mL

form 

solid film

pka

3.03±0.70(Predicted)

color 

Off-white

Stability:

Stable for 1 year from date of purchase as supplied. Solutions in DMSO, methanol or ethanol may be stored at -20°C for up to 2 months.

IARC

2B (Vol. 94) 2010

EPA Substance Registry System

Microcystin LR (101043-37-2)

Safety Information

Hazard Codes 

T+,T,F

Risk Statements 

26/27/28-36/37/38-43-39/23/24/25-23/24/25-11

Safety Statements 

26-36/37/39-45-36/37-16-7

RIDADR 

UN 2811 6.1/PG 1

WGK Germany 

3

RTECS 

GT2810000

HS Code 

30029090

Hazardous Substances Data

101043-37-2(Hazardous Substances Data)

Toxicity

LD50 orl-rat: >5 mg/kg HETOEA 18,162,1999

MSDS

• Language:English Provider:SigmaAldrich

MICROCYSTIN-LR Usage And Synthesis

Description

Microcystins are hepatotoxic cyclic heptapeptide toxins produced by cyanobacteria. They are responsible for periodic poisonings of humans and livestock drinking fresh water where the blue-green algae are endemic. Microcystin-LR is a selective inhibitor of protein phosphatase 2A (PP2A) (IC₅₀= 0.04 nM) and will completely inhibit this enzyme without affecting PP1 when used at a concentration of 0.5 nM. The PP1 IC₅₀ is about 1.7 nM. Microcystins are at least 10 times more potent as serine/threonine PP inhibitors than okadaic acid, another microalgal toxin also used for this purpose.

Definition

ChEBI: Microcystin-LR is a microcystin consisting of D-alanyl, L-leucyl, (3S)-3-methyl-D-beta-aspartyl,L-arginyl, 2S,3S,4E,6E,8S,9S)-3-amino-4,5,6,7-tetradehydro-9-methoxy-2,6,8-trimethyl-10-phenyldecanoyl, D-gamma-glutamyl, and 2,3-didehydro-N-methylalanyl residues joined into a 25-membered macrocycle. Produced by the cyanobacterium Microcystis aeruginosa, it is the most studied of the microcystins. It has a role as a bacterial metabolite, an EC 3.1.3.16 (phosphoprotein phosphatase) inhibitor, a xenobiotic and an environmental contaminant.

Hazard

A poison by ingestion and inhalation.

Safety Profile

A poison by ingestion, inhalation,intraperitoneal, and intravenous route. Experimentalreproductive effects. When heated to decomposition itemits toxic vapors of NOx.

References

1) Rinehart?et al.?(1988),?Nodularin, microcystin, and the configuration of Adda; J. Am. Chem. Soc.,?110?8557 2) Honkanen?et al. (1990),?Characterization of microcystin-LR, a potent inhibitor of type 1 and type 2A protein phosphatases;?J. Biol. Chem,?265?19401 3) Runnegar?et al.?(1995),?Microcystin uptake and inhibition of protein phosphatases: effects of chemoprotectants and self-inhibition in relation to known hepatic transporters; Toxicol. Appl. Pharmacol.,?134?264

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