2-Fluoro-N-(3-fluoro-5-pyridin-2-yl-benzoyl)-benzenesulfonhydrazine Chemical Properties

Density 

1.414±0.06 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

DMSO:30.0(Max Conc. mg/mL);76.97(Max Conc. mM)

form 

A crystalline solid

pka

6.79±0.25(Predicted)

color 

Off-white to light yellow

2-Fluoro-N-(3-fluoro-5-pyridin-2-yl-benzoyl)-benzenesulfonhydrazine Usage And Synthesis

Uses

WM 1119 is a highly potent and selective inhibitor of lysine acetyltransferases, KAT6A and KAT6B.

Biological Activity

WM-1119 is a potent and selective, acetyl coenzyme A (Acetyl-CoA)-competitive inhibitor against MYST family histone acetyltransferases KAT6A and KAT6B (KAT6B Kd = 2.1 nM by SPR, IC50 = 37 nM by activity assay; KAT7/5 Kd = 0.53/2.2 μM; no affinity toward 159 diverse biological targets). WM-1119 induces MEF G1 cell cycle arrest (1-10 μM), inhibits EMRK1184 lymphoma growth in cultures (IC50 = 250 nM) and in mice in vivo (50 mg/kg 3x or 4x i.p. per day).

storage

Store at +4°C

2-Fluoro-N-(3-fluoro-5-pyridin-2-yl-benzoyl)-benzenesulfonhydrazine(2055397-28-7)Related Product Information

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