Cereblon Ligand 1 Chemical Properties

Boiling point:

660.5±55.0 °C(Predicted)

Density 

1.606±0.06 g/cm3(Predicted)

solubility 

Soluble in DCM

form 

A crystalline solid

pka

2.95±0.10(Predicted)

color 

White to off-white

InChI

InChI=1S/C15H12N2O7/c18-10-5-4-8(13(21)16-10)17-14(22)7-2-1-3-9(12(7)15(17)23)24-6-11(19)20/h1-3,8H,4-6H2,(H,19,20)(H,16,18,21)

InChIKey

ZVWIXIGBWIEDFO-UHFFFAOYSA-N

SMILES

C(O)(=O)COC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O

Safety Information

HS Code 

2933998090

Cereblon Ligand 1 Usage And Synthesis

Description

Thalidomide-Acid (Cereblon Ligand 1) is a linker of Thalidomide which is commonly used as a precursor to PROTAC that hijacks cereblon as the E3 ubiquitin ligase component.

Uses

Thalidomide-4-hydroxyacetate (Cereblon Ligand 1) is a proteolysis targeting chimeras which allows for the optical control of protein degradation.

Solubility in organics

DMF: 30 mg/ml
DMSO: 30 mg/ml
PBS (pH 7.2): 1 mg/ml

storage

Store at RT

Cereblon Ligand 1(1061605-21-7)Related Product Information

• 1H-Isoindole-1,3(2H)-dione, 4-[2-(2-aminoethoxy)ethoxy]-2-(2,6-dioxo-3-piperidinyl)-
• E3 Ligase Ligand-Linker Conjugates 21
• E3 Ligase Ligand-Linker Conjugates 19
• Thalidomide-O-PEG4-Propargyl
• Thalidomide-linker 10
• Acetamide, 2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-N-3,6,9,12-tetraoxapentadec-14-yn-1-yl-
• Thalidomide-O-amido-C4-NH2 hydrochloride
• Thalidomide-O-amido-PEG3-C2-NH2 hydrochloride
• Thalidomide-O-amido-C8-NH2 hydrochloride
• Thalidomide-O-PEG4-Boc
• tert-butyl 3,3'-(2-aMino-2-((3-tert-butoxy-3-oxopropoxy)Methyl)propane-1,3-diyl)bis(oxy)dipropanoate
• Thalidomide-linker 13
• E3 Ligase Ligand-Linker Conjugates 20
• 4-Hydroxy ThalidoMide
• Protein degrader 1 (TFA)
• (2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride
• 2-(2,6-dioxopiperidin-3-yl)-4-fluoroisoindoline-1,3-dione
• L-Prolinamide, 3-methyl-L-valyl-4-hydroxy-N-[(1S)-1-[4-(4-methyl-5-thiazolyl)phenyl]ethyl]-, (4R)-