AURANTIMYCIN A
AURANTIMYCIN A Basic information
- Product Name:
- AURANTIMYCIN A
- Synonyms:
-
- AURANTIMYCIN A
- D-Alanine, (3S)-3-hydroxy-N-[(2R)-2-hydroxy-1-oxo-2-[(2S,5S,6S)-tetrahydro-2-hydroxy-6-methyl-5-(2-methylpropyl)-2H-pyran-2-yl]propyl]-L-leucyl-(3R)-hexahydro-3-pyridazinecarbonyl-N-hydroxy-O-methyl-L-serylglycyl-(3S)-hexahydro-3-pyridazinecarbonyl-N-hydroxy-, (6→13)-lactone
- Aurantimycin A, Depsipeptide antibiotic
- CAS:
- 162478-50-4
- MF:
- C38H64N8O14
- MW:
- 856.96
- Mol File:
- 162478-50-4.mol
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AURANTIMYCIN A Chemical Properties
- Density
- 1.38±0.1 g/cm3(Predicted)
- pka
- 8.36±0.70(Predicted)
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AURANTIMYCIN A Usage And Synthesis
Uses
Aurantimycin A (Adipogen), a depsipeptide antibiotic, displays strong activity against Gram-positive bacteria. Aurantimycin A is a substrate of the LieAB transporter[1][2].
References
[1] U Gr?fe, et al. Aurantimycins, new depsipeptide antibiotics from Streptomyces aurantiacus IMET 43917. Production, isolation, structure elucidation, and biological activity. J Antibiot (Tokyo). 1995 Feb;48(2):119-25. DOI:10.7164/antibiotics.48.119
[2] Samuel Hauf, et al.Aurantimycin resistance genes contribute to survival of Listeria monocytogenes during life in the environment. Mol Microbiol. 2019 Apr;111(4):1009-1024. DOI:10.1111/mmi.14205
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