7-BROMO-5-NITROINDOLE Chemical Properties

Boiling point:

402.3±25.0 °C(Predicted)

Density 

1.855±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

pka

13.58±0.30(Predicted)

Appearance

Light yellow to yellow Solid

Safety Information

Hazard Codes 

Xi,T

Risk Statements 

25

Safety Statements 

45

HazardClass 

IRRITANT

7-BROMO-5-NITROINDOLE Usage And Synthesis

Synthesis

General procedure for the synthesis of 7-bromo-5-nitro-1H-indole from 7-bromo-5-nitroindole: 7-bromo-5-nitroindole (3 g, 12.34 mmol) was dissolved in ethanol (30 mL), DDQ (5.6 g, 24.69 mmol) and isopropanol (2 mL) were added. The reaction mixture was stirred at 80 °C for 48 hours. Upon completion of the reaction, the reaction mixture was concentrated under reduced pressure and the residue was partitioned between ethyl acetate and water. The organic layer was separated, washed with water, dried over anhydrous sodium sulfate, filtered and the filtrate concentrated under reduced pressure. The crude product was purified by fast chromatography using a hexane solution of 20% ethyl acetate as eluent to give the title compound (2.5 g, 84%) as a yellow solid.1H NMR (300 MHz, DMSO-d6): δ 12.13 (bs, 1H), 8.62 (d, J=1.8 Hz, 1H), 8.18 (d, J=1.8 Hz, 1H) , 7.67 (t, J=3.0Hz, 1H), 6.89 (m, 1H).ESI-MS m/z=241 (M+H)+.

References

[1] Phytochemistry (Elsevier), 1982, vol. 21, # 12, p. 2879 - 2886
[2] Patent: US2014/148437, 2014, A1. Location in patent: Paragraph 0237; 0240-0241
[3] Patent: WO2014/81994, 2014, A1. Location in patent: Page/Page column 50

7-BROMO-5-NITROINDOLE(87240-07-1)Related Product Information

• 7-BROMO-1H-INDOL-5-AMINE
• 7-BROMO-5-NITROINDOLE
• 1-ACETYL-7-BROMO-5-NITROINDOLE