3-Bromo-6-methoxy-2-picoline Chemical Properties

Boiling point:

86°C/10mmHg(lit.)

Density 

1.468g/mLat 25℃

refractive index 

n20/D 1.548

Flash point:

106°C

storage temp. 

2-8°C

pka

1.76±0.10(Predicted)

form 

Liquid

color 

Colorless

InChI

InChI=1S/C7H8BrNO/c1-5-6(8)3-4-7(9-5)10-2/h3-4H,1-2H3

InChIKey

VWNXCCTWVAQAPL-UHFFFAOYSA-N

SMILES

C1(C)=NC(OC)=CC=C1Br

CAS DataBase Reference

126717-59-7(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi,Xn

Risk Statements 

41-22

Safety Statements 

26-39

WGK Germany 

3

HazardClass 

IRRITANT

HS Code 

2933399990

3-Bromo-6-methoxy-2-picoline Usage And Synthesis

Synthesis

A mixture of 5-bromo-6-methyl-1H-pyridin- 2-one (5.5 g, 29 mmol), silver carbonate (10.89 g, 39 mmol), iodomethane (13.6 mL, 217 mmol) and chloroform (115 mL) is stirred overnight in the dark at room temperature. Triethylamine (10 mL) is added, and stirring is continued for 1.5 hr. The reaction mixture is filtered through a pad of Hi-Flo, and the filtrate is washed with water (100 mL), dried, filtered and concentrated. The residue is purified by filtration through a pad of silica gel washing with cyclohexane-20percent ethyl acetate. The solvent is concentrated to afford 3-Bromo-6-methoxy-2-picoline (3.7 g, 63percent yield) as an oil.

References

[1] Patent: WO2005/51954, 2005, A2. Location in patent: Page/Page column 39; 40

3-Bromo-6-methoxy-2-picoline(126717-59-7)Related Product Information

• Chromium picolinate
• 5-Amino-2-methoxypyridine
• 5-Bromo-2-methylpyridine
• 2,4,6-Collidine
• 2-Chloro-5-chloromethylpyridine
• 2-Methoxy-5-nitropyridine
• 2-Methoxypyridine
• 5-Bromo-2-methoxypyridine
• 4-Methylpyridine
• 2-Methoxy-6-methylaminopyridine
• 2-Bromo-6-methoxypyridine
• 2-Methoxy-5-fluoropyridine
• 2,6-Lutidine
• Azamethiphos
• 1-Hexadecylpyridinium bromide
• 2-Methoxy-5-(trifluoromethyl)pyridine
• 4-CHLORO-2-METHOXY-PYRIDINE
• 2-Methoxy-4-methylpyridine