[LEU5]-ENKEPHALIN Chemical Properties

Melting point:

130-133 °C

alpha 

+32.3°(c=9,メタノール)

Boiling point:

998.8±65.0 °C(Predicted)

Density 

1.274±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Sealed in dry,Store in freezer, under -20°C

solubility 

≥54.6 mg/mL in H2O; ≥54.8 mg/mL in EtOH; ≥55.6 mg/mL in DMSO

form 

Lyophilized powder

pka

3.40±0.10(Predicted)

color 

White to light yellow

Water Solubility 

Soluble in water (1 mg/ml ).

Sequence

H-Tyr-Gly-Gly-Phe-Leu-OH

Safety Information

Safety Statements 

22-24/25

WGK Germany 

3

F 

3-10-21

MSDS

• Language:English Provider:SigmaAldrich

[LEU5]-ENKEPHALIN Usage And Synthesis

Uses

Endogenous opioid neurotransmitter/neuromodulator that is an agonist at ? and δ opioid receptors, localization in brain parallels the localization of δ receptors.

Definition

ChEBI: Leu-enkephalin is a pentapeptide comprising L-tyrosine, glycine, glycine, L-phenylalanine and L-leucine residues joined in sequence by peptide linkages. It is an endogenous opioid peptide produced in vertebrate species, including rodents, primates and humans that results from decomposition of proenkephalin or dynorphin and exhibits antinociceptive properties. It has a role as a delta-opioid receptor agonist, a mu-opioid receptor agonist, a neurotransmitter, an analgesic, a human metabolite and a rat metabolite. It is functionally related to a L-tyrosine, a glycine, a L-phenylalanine and a L-leucine. It is a tautomer of a Leu-enkephalin zwitterion.

storage

Store at -20°C

[LEU5]-ENKEPHALIN(58822-25-6)Related Product Information

• H-TYR-LYS-GLY-ARG-CYCLO(-GLU-TYR-ILE-LYS)-LEU-ILE-THR-ARG-PRO-ARG-TYR-NH2
• MET-ENKEPHALIN-ARG-ARG
• LEU-ENKEPHALIN-ARG
• ADRENORPHIN
• H-TYR-GLY-GLY-PHE-LEU-ARG-ARG-OH
• ADRENORPHIN
• MET-ENKEPHALIN-ARG-PHE
• (MET(O)5)-ENKEPHALIN
• motilin-related peptide
• Semax
• Ghrelin
• arg(6)-gly(7)-leu(8)-enkephalin-m
• D-ALA2-LEU5-ENKEPHALIN
• LEUCINE ENKEPHALIN ACETATE SALT
• (D-ALA2, D-LEU5)-ENKEPHALIN ACETATE,[D-ALA2, D-LEU5]-ENKEPHALIN ACETATE SALT
• (D-ALA2,D-LEU5)-ENKEPHALIN,[D-ALA2,D-LEU5]-ENKEPHALIN ACOH H2O
• [LEU5]-ENKEPHALIN AMIDE
• ALPHA-CASEIN (90-95)