2-AMINO CYCLOPENTANOL Chemical Properties

Boiling point:

114-115℃ (13 Torr)

Density 

1.0617 g/cm3(Temp: 15 °C)

refractive index 

1.4965 (589.3 nm 15℃)

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

pka

14.93±0.40(Predicted)

Appearance

Colorless to light yellow Liquid

CAS DataBase Reference

89381-13-5(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn

Risk Statements 

22-37/38-41

Safety Statements 

26-39

RIDADR 

UN3082

HazardClass 

9

2-AMINO CYCLOPENTANOL Usage And Synthesis

Uses

2-Aminocyclopentanol can be used as a pharmaceutical synthesis intermediate. It can be prepared from cyclopentane oxide as a reaction raw material. It can be used to prepare 5-methyl-2-(pyridin-2-ylamino)-8H-pyrido[2,3-d]pyrimidin-7-one compounds. It can also be used to prepare drugs for treating diseases related to cyclin-dependent kinase signaling pathways.

Synthesis

General procedure for the synthesis of (1S,2S)-2-aminocyclopentanol from the compound (CAS:672310-36-0): 0.900 g (3.82 mmol) of (S,S)-2-benzyloxycarbonylaminocyclopentanol and 0.36 g of 5% palladium-carbon catalyst were added to the reaction system in a 50 mL autoclave. Under nitrogen protection, 4.5 mL of degassed methanol was added to the reaction system. The reaction mixture was stirred at 50 °C for 3 hours under hydrogen pressure of 2 MPa. Upon completion of the reaction, the palladium-carbon catalyst was removed by diatomaceous earth filtration, and the filtrate was concentrated by rotary evaporator to give 0.59 g of crude product. The product was determined to have an enantiomeric excess (ee) percentage of more than 99%. The 1H-NMR (200 MHz, CDCl3) data of the product were as follows: δ 1.2-1.3 (m, 1H), 1.5 (m, 1H), 1.6-1.7 (m, 2H), 1.9-2.0 (m, 2H), 2.3-2.5 (br, 3H), 3.0 (m, 1H), 3.7 (m, 1H).

References

[1] Patent: EP1398310, 2004, A1. Location in patent: Page 16-17

2-AMINO CYCLOPENTANOL(89381-13-5)Related Product Information

• METHYLLYCACONITINE CITRATE
• 2-AMINO CYCLOPENTANOL
• Pancuronium bromide
• DELCORINE
• (1R,2S)-cis-2-Aminocyclopentanol hydrochloride
• (1S,2S)-trans-2-Aminocyclopentanol hydrochloride
• cis-(1S,2R)-2-Aminocyclopentanol hydrochloride
• CIS-2-AMINO-CYCLOPENTANOL HYDROCHLORIDE
• TRANS-(1R,2R)-2-AMINO-CYCLOPENTANOL HCL
• TRANS-(1R,2R)-2-AMINO-CYCLOPENTANOL HCL
• Cyclopentanol
• 14-ACETYLVIRESCENINE
• LYCACONITINE PERCHLORATE
• NUDIKAULINE PERCHLORATE
• METHYLLYCACONITINE PERCHLORATE
• MANNOSTATIN A, HYDROCHLORIDE
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