1-(6-Chloro-pyridazino-3-yl)piperidine Chemical Properties

Melting point:

80～82℃

Boiling point:

388.6±27.0 °C(Predicted)

Density 

1.234±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

pka

3.62±0.10(Predicted)

Safety Information

Hazard Codes 

Xi

HazardClass 

IRRITANT

HS Code 

2933998090

1-(6-Chloro-pyridazino-3-yl)piperidine Usage And Synthesis

Synthesis

GENERAL METHOD: Anhydrous ethanol (5 mL) and 3,6-dichloropyridazine (3.36 mmol) were added to a 50 mL round-bottomed flask, followed by triethylamine (5.03 mmol) and hexahydropyridine (5.03 mmol). The reaction mixture was stirred under ethanol reflux conditions for 3,6-dichloropyridazine and 3,6-dichloropyrazine and at room temperature for 3,6-dichloropyrimidine. The reaction process was monitored by gas chromatography (GC). When the starting material 3,6-dichloropyridazine was completely consumed, the reaction mixture was poured into saturated ammonium chloride solution (20 mL) and extracted with dichloromethane (3 x 20 mL). The organic layers were combined, dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The crude product was ground with petroleum ether and filtered through a Büchner funnel to give pure 1-(6-chloropyridazin-3-yl)piperidine.

References

[1] Tetrahedron, 2015, vol. 71, # 29, p. 4859 - 4867
[2] Journal of Organic Chemistry, 2013, vol. 78, # 2, p. 370 - 379
[3] European Journal of Medicinal Chemistry, 2015, vol. 95, p. 277 - 301
[4] Yakugaku Zasshi, 1954, vol. 74, p. 1195,1197
[5] Chem.Abstr., 1955, p. 14768

1-(6-Chloro-pyridazino-3-yl)piperidine(1722-11-8)Related Product Information

• Hydrochlorothiazide
• Sulfachloropyridazine sodium
• Sulfamethoxypyridazine
• Thioridazine
• Pyridaphenthion
• METHYL 1-(6-CHLORO-3-PYRIDAZINYL)-4-PIPERIDINECARBOXYLATE
• 1-(6-Chloro-3-pyridazinyl)-4-piperidinecarboxamide
• Difluorochloromethane
• Piperidine
• 1-(6-Chloro-3-pyridazinyl)-4-piperidinol
• ETHYL 1-(6-CHLORO-3-PYRIDAZINYL)-4-PIPERIDINECARBOXYLATE
• 1-CHLORO-4-PIPERIDIN-1-YL-PHTHALAZINE
• 1-(6-CHLORO-3-PYRIDAZINYL)-4-PIPERIDINECARBOXYLIC ACID
• 1-(6-CHLORO-3-PYRIDAZINYL)-N-(HEXAHYDRO-2H-ISOXAZOLO[2,3-A]PYRIDIN-2-YLMETHYL)-4-PIPERIDINECARBOXAMIDE
• 1-(6-CHLORO-3-PYRIDAZINYL)TETRAHYDRO-4(1H)-PYRIDINONE
• 1-(6-CHLORO-3-PYRIDAZINYL)-4-PIPERIDINECARBOHYDRAZIDE
• 1-(6-Chloro-pyridazino-3-yl)piperidine
• 1-(6-CHLORO-PYRIDAZIN-3-YL)-PIPERIDINE-3-CARBOXYLIC ACID METHYL ESTER