4-DIMETHOXYMETHYLPYRIMIDIN-2-YLAMINE Chemical Properties

Boiling point:

295.3±48.0 °C(Predicted)

Density 

1.200±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

pka

3.34±0.10(Predicted)

form 

solid

color 

Off-white

InChI

InChI=1S/C7H11N3O2/c1-11-6(12-2)5-3-4-9-7(8)10-5/h3-4,6H,1-2H3,(H2,8,9,10)

InChIKey

OQINWXZQCAIVNK-UHFFFAOYSA-N

SMILES

C1(N)=NC=CC(C(OC)OC)=N1

Safety Information

HS Code 

2933599590

4-DIMETHOXYMETHYLPYRIMIDIN-2-YLAMINE Usage And Synthesis

Uses

4-Dimethoxymethylpyrimidin-2-ylamine is a useful research chemical.

Synthesis

1. Acetone aldehyde dimethyl acetal (10 g, 84 mmol) and N,N-dimethylformamide dimethyl acetal (10 g, 84 mmol) were dissolved in DMF (30 ml) in a round-bottomed flask and the reaction was heated for 15 h at 110 °C. 2. an aqueous solution of guanidine hydrochloride (12 g, 127 mmol) and NaOH (6.7 g, 169 mmol) was added to the reaction mixture. 3. The mixture was refluxed for 36 hours. 4. After completion of the reaction, the reaction material was cooled and filtered. 5. The product was purified by recrystallization from hot ethyl acetate to afford 2-amino-4-dimethoxymethylpyrimidine (10 g, 70% yield) as a white crystalline solid.

References

[1] Tetrahedron Letters, 2013, vol. 54, # 28, p. 3715 - 3717
[2] Patent: EP1227092, 2002, A2. Location in patent: Page 25
[3] Patent: EP1229035, 2002, A1. Location in patent: Page 25
[4] Patent: EP1227091, 2002, A2. Location in patent: Page 25
[5] Patent: WO2007/104053, 2007, A2. Location in patent: Page/Page column 36-37

4-DIMETHOXYMETHYLPYRIMIDIN-2-YLAMINE(165807-05-6)Related Product Information

• 2-Amino-4,6-dimethylpyrimidine
• Carbohydrazide
• 4-DIMETHOXYMETHYLPYRIMIDIN-2-YLAMINE
• 4-(DIMETHOXYMETHYL)PYRIMIDINE
• 2-(METHYLAMINO)PYRIMIDINE-4-CARBOXALDEHYDE DIMETHYL ACETAL
• 2-AMINO-5-BROMO-4-DIMETHOXYMETHYLPYRIMIDINE