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POLYOXIN A

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POLYOXIN A Basic information

Product Name:
POLYOXIN A
Synonyms:
  • 3,4-dihydro-5-(hydroxymethyl)-2,4-dioxo-1(2h)-pyrimidinyl)-beta-d-allofuranuro
  • monocarbamate(ester),(e)-l-noyl)-3-ethylidene
  • 1-(5-(2-amino-2-deoxy-l-xylonamido)-1,5-dideoxy-1-(3,4-dihydro-5-(hydroxymethyl)-2,4-dioxo-1(2h)-pyr2-azetidinecarboxylic aci
  • POLYOXIN A
  • 2-azetidinecarboxylicacid,1-(5-(2-amino-2-deoxy-l-xylonamido)-1,5-dideoxy-1-(
  • 2-Azetidinecarboxylic acid, 1-[5-[[2-amino-5-O-(aminocarbonyl)-2-deoxy-L-xylonoyl]amino]-1,5-dideoxy-1-[3,4-dihydro-5-(hydroxymethyl)-2,4-dioxo-1(2H)-pyrimidinyl]-β-D-allofuranuronoyl]-3-ethylidene-, (2S,3Z)-
  • POLYOXIN A USP/EP/BP
CAS:
19396-03-3
MF:
C23H32N6O14
MW:
616.53
Mol File:
19396-03-3.mol
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POLYOXIN A Chemical Properties

alpha 
D20 -30°
Density 
1.748±0.06 g/cm3(Predicted)
pka
3.07±0.20(Predicted)
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Safety Information

Toxicity
Acute oral LD50>20000mg/kg in rats and mice, acute transdermal LD50>12000mg/kg in rats, acute inhalation LD50 in rats >10mg/L. No irritation to rabbit eyes and skin. No carcinogenic, teratogenic or mutagenic effects were found in animal experiments. Carp LC50>40mg/L (48h), Daphnia LC50>40mg/L (3h). Low toxicity to bees, LD50>1000mg/bee.
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POLYOXIN A Usage And Synthesis

Chemical Properties

Colorless needle crystal, m.p.180°C or amorphous crystal, m.p.160°C (decomposition). POLYOXIN A is easily soluble in water, but insoluble in organic solvents such as methanol, ethanol, acetone, chloroform, benzene and ether. It is stable to ultraviolet light, acidic solution and neutral solution, unstable to alkaline solution, and stable for more than 3 years when stored at room temperature. The appearance of the industrial product is light brown powder or taupe powder.

Uses

POLYOXIN A is a broad-spectrum antibiotic fungicide with systemic conduction. It is mainly used to control wheat powdery mildew, ginseng black spot, tobacco red spot, cucumber downy mildew, melon wilt, rice sheath blight, apple spotted leaf spot, strawberry and grape gray mold, forest sheath wilt, etc.

Synthesis

POLYOXIN A can be obtained by the method: connect the sand pipe to the slope (aseptic operation) and cultivate it at a constant temperature of 28°C. After the spores grow and mature, connect the slope spores to the slope again. After constant temperature cultivation, it will be the slope for production; tank), fermentation (fermentation tank), acidification, concentration, spray drying and crushing.

POLYOXIN ASupplier

BOC Sciences
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1-631-485-4226; 16314854226
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Shaanxi Dideu Medichem Co. Ltd
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+86-029-89586680 +86-18192503167
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1026@dideu.com
SIMAGCHEM CORP
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+86-13806087780
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sale@simagchem.com
Zhejiang Huida Biotech Co., LTD
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0571-89903882 13626641628
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jiangnan@huidabiotech.com
Zhejiang Huida Biotech Co., LTD
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0571-0571-89903882 15990081639
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sunshixuan@huidabiotech.com