ANTIMYCIN A1
ANTIMYCIN A1 Basic information
- Product Name:
- ANTIMYCIN A1
- Synonyms:
-
- dihydrosamidin
- -dioxo-1,5-dioxonan-3-yl)salicylamide
- isovalericacid,8-esterwith3-formamido-n-(7-hexyl-8-hydroxy-4,9-dimethyl-2,6
- ANTIMYCIN A1
- 3-(3-formamidosalicylamido)-8-hexyl-2,6-dimethyl-4,9-dioxo-1,5-dioxonan-7-yl isovalerate
- 3-Methylbutanoic acid 3-[[3-(formylamino)-2-hydroxybenzoyl]amino]-8-hexyl-2,6-dimethyl-4,9-dioxo-1,5-dioxonan-7-yl ester
- 3-Methylbutyric acid 3-[[3-(formylamino)-2-hydroxybenzoyl]amino]-8-hexyl-2,6-dimethyl-4,9-dioxo-1,5-dioxonan-7-yl ester
- [3-[(3-formamido-2-hydroxybenzoyl)amino]-8-hexyl-2,6-dimethyl-4,9-dioxo-1,5-dioxonan-7-yl] 3-methylbutanoate
- CAS:
- 642-15-9
- MF:
- C28H40N2O9
- MW:
- 548.63
- EINECS:
- 211-380-4
- Mol File:
- 642-15-9.mol
ANTIMYCIN A1 Chemical Properties
- Melting point:
- 149.5℃
- alpha
- D26 +76° (c = 1 in chloroform)
- Boiling point:
- 620.81°C (rough estimate)
- Density
- 1.2468 (rough estimate)
- refractive index
- 1.5800 (estimate)
- storage temp.
- −20°C
- solubility
- DMF: Soluble; DMSO: Soluble; Ethanol: Soluble; Methanol: Soluble
- form
- A solid
Safety Information
- Hazard Codes
- T
- Risk Statements
- 23/24/25
- Safety Statements
- 36/37/39-45
- RIDADR
- 3172
- RTECS
- NY1503500
- HazardClass
- 6.1(a)
- PackingGroup
- II
ANTIMYCIN A1 Usage And Synthesis
Description
Antimycin A1 is an active component of the antimycin A antibiotic complex. It inhibits electron transport and is active against the plant pathogenic fungus G. cingulate. Antimycin A1 (3.3-160 μM) induces the synthesis of carotenoids in M. marinum. It also inhibits ATP-citrate lyase (Ki = 29.5 μM).
Chemical Properties
Antimycin (A3C26H36N2O9) and (Antimycin A1) C28H40N2O9 are crystalline solids.
Chemical Properties
Crystals. Soluble in alcohol, ether, acetone, and chloroform; slightly soluble in benzene, carbon tetrachloride, and petroleum ether; insoluble in water.
Uses
Antimycin A1 is the most hydrophobic of the four analogues of the antimycin A complex. Like all antimycins, antimycin A1 exhibits potent antifungal, anthelmintic, insecticidal, antiviral and antitumor activity across a range of bioassays. Although broadly active as respiration inhibitors, more recent investigation has highlighted the importance of individual members of the complex as bioprobes. Antimycin A1 inhibits angiogenesis via a decrease in VEGF production caused by inhibition of HIF-1a activation.
Uses
Experimentally as fungicide, insecticide, miticide.
Definition
An antibiotic substance said to have strong fungicidal properties.
Potential Exposure
Specific uses for antimycin A were not found, however, antimycin A1, and antimycin A3 are reported to be antibiotic substances produced by streptomyces for use as a fungicide, possible insecticide and miticide. Registered as a pesticide in the U.S.
Shipping
UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.
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ANTIMYCIN A1(642-15-9)Related Product Information
- ANTIMYCIN A1
- Salicyluric acid
- ETHYL 4-ACETOXYBUTANOATE
- GLYCINE N-BUTYL ESTER HYDROCHLORIDE
- FEMA 3506
- Isobutyl isovalerate
- ANTIMYCIN,ANTIMYCIN A FROM STREPTOMYCES SP.,ANTIMYCIN A
- citrinin,antimyci
- FEMA 2814
- BENZOYL-DL-A-ALANINE ETHYL ESTER
- DL-3-ACETOXYBUTYRIC ACID ETHYL ESTER
- 3-amino-N-(isopropyl)benzamide
- N-[3-(AMINOMETHYL)PHENYL]-N-METHYLAMINE
- ETHYL 2-(BENZYLAMINO)PROPANOATE
- ANTIMYCIN A2
- 3-(2-ethylbutoxy)propionic acid
- N-(2-HYDROXYETHYL)SALICYLAMIDE, 98
- N-ISOPROPYLSALICYLAMIDE