Basic information Safety Supplier Related

ANTIMYCIN A1

Basic information Safety Supplier Related

ANTIMYCIN A1 Basic information

Product Name:
ANTIMYCIN A1
Synonyms:
  • dihydrosamidin
  • -dioxo-1,5-dioxonan-3-yl)salicylamide
  • isovalericacid,8-esterwith3-formamido-n-(7-hexyl-8-hydroxy-4,9-dimethyl-2,6
  • ANTIMYCIN A1
  • 3-(3-formamidosalicylamido)-8-hexyl-2,6-dimethyl-4,9-dioxo-1,5-dioxonan-7-yl isovalerate
  • 3-Methylbutanoic acid 3-[[3-(formylamino)-2-hydroxybenzoyl]amino]-8-hexyl-2,6-dimethyl-4,9-dioxo-1,5-dioxonan-7-yl ester
  • 3-Methylbutyric acid 3-[[3-(formylamino)-2-hydroxybenzoyl]amino]-8-hexyl-2,6-dimethyl-4,9-dioxo-1,5-dioxonan-7-yl ester
  • [3-[(3-formamido-2-hydroxybenzoyl)amino]-8-hexyl-2,6-dimethyl-4,9-dioxo-1,5-dioxonan-7-yl] 3-methylbutanoate
CAS:
642-15-9
MF:
C28H40N2O9
MW:
548.63
EINECS:
211-380-4
Mol File:
642-15-9.mol
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ANTIMYCIN A1 Chemical Properties

Melting point:
149.5℃
alpha 
D26 +76° (c = 1 in chloroform)
Boiling point:
620.81°C (rough estimate)
Density 
1.2468 (rough estimate)
refractive index 
1.5800 (estimate)
storage temp. 
−20°C
solubility 
DMF: Soluble; DMSO: Soluble; Ethanol: Soluble; Methanol: Soluble
form 
A solid
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Safety Information

Hazard Codes 
T
Risk Statements 
23/24/25
Safety Statements 
36/37/39-45
RIDADR 
3172
RTECS 
NY1503500
HazardClass 
6.1(a)
PackingGroup 
II
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ANTIMYCIN A1 Usage And Synthesis

Description

Antimycin A1 is an active component of the antimycin A antibiotic complex. It inhibits electron transport and is active against the plant pathogenic fungus G. cingulate. Antimycin A1 (3.3-160 μM) induces the synthesis of carotenoids in M. marinum. It also inhibits ATP-citrate lyase (Ki = 29.5 μM).

Chemical Properties

Antimycin (A3C26H36N2O9) and (Antimycin A1) C28H40N2O9 are crystalline solids.

Chemical Properties

Crystals. Soluble in alcohol, ether, acetone, and chloroform; slightly soluble in benzene, carbon tetrachloride, and petroleum ether; insoluble in water.

Uses

Antimycin A1 is the most hydrophobic of the four analogues of the antimycin A complex. Like all antimycins, antimycin A1 exhibits potent antifungal, anthelmintic, insecticidal, antiviral and antitumor activity across a range of bioassays. Although broadly active as respiration inhibitors, more recent investigation has highlighted the importance of individual members of the complex as bioprobes. Antimycin A1 inhibits angiogenesis via a decrease in VEGF production caused by inhibition of HIF-1a activation.

Uses

Experimentally as fungicide, insecticide, miticide.

Definition

An antibiotic substance said to have strong fungicidal properties.

Potential Exposure

Specific uses for antimycin A were not found, however, antimycin A1, and antimycin A3 are reported to be antibiotic substances produced by streptomyces for use as a fungicide, possible insecticide and miticide. Registered as a pesticide in the U.S.

Shipping

UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.

ANTIMYCIN A1Supplier

Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
18521735133 18521732826;
Email
market@aladdin-e.com
Lynnchem
Tel
86-(0)29-85992781 17792393971
Email
info@lynnchem.com
Novachemistry
Tel
44-20819178-90 02081917890
Email
info@novachemistry.com
Shanghai Hongye Biotechnology Co. Ltd
Tel
400-9205774
Email
sales@glpbio.cn
Shenzhen Polymeri Biochemical Technology Co., Ltd.
Tel
+86-400-002-6226 13028896684
Email
sales@rrkchem.com
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ANTIMYCIN A1(642-15-9)Related Product Information