6-FLUOROQUINAZOLIN-4-ONE Chemical Properties

Melting point:

250 °C

Boiling point:

318.3±44.0 °C(Predicted)

Density 

1.44±0.1 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

pka

1.28±0.20(Predicted)

Appearance

Off-white to light yellow Solid

Safety Information

Hazard Codes 

Xn

Risk Statements 

22

HazardClass 

IRRITANT

HS Code 

2933992000

6-FLUOROQUINAZOLIN-4-ONE Usage And Synthesis

Synthesis

General procedure for the synthesis of 6-fluoro-4-hydroxyquinazoline from 2-amino-5-fluorobenzoic acid and the compound (CAS: 77287-34-4): operate with reference to the reaction and post-processing of Example 5, substituting only the type of o-aminobenzoic acid derivative. The specific experimental results are detailed in Table 4.

References

[1] Patent: EP1997812, 2008, A1. Location in patent: Page/Page column 8
[2] European Journal of Medicinal Chemistry, 2012, vol. 50, p. 264 - 273
[3] Molecules, 2006, vol. 11, # 6, p. 383 - 392
[4] Bioorganic and Medicinal Chemistry, 2007, vol. 15, # 11, p. 3768 - 3774
[5] Chemistry and Biodiversity, 2018, vol. 15, # 6,

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