(2E)-TCO-PNB ester
(2E)-TCO-PNB ester Basic information
- Product Name:
- (2E)-TCO-PNB ester
- Synonyms:
-
- (2E)-TCO-PNB ester
- TCO*A - active ester (p-NPE)
- TCO*A - active ester (p-NPC)
- Carbonic acid, (2E)-2-cycloocten-1-yl 4-nitrophenyl ester
- (E)-Cyclooct-2-en-1-yl (4-nitrophenyl) carbonate
- rel-(1R-2E-pS)-axial-Cyclooct-2-en-1-yl (4-nitrophenyl) carbonate
- 2-Cyclooctenyl (E)-(4-Nitrophenyl) Carbonate
- CAS:
- 1580501-97-8
- MF:
- C15H17NO5
- MW:
- 291.3
- Product Categories:
-
- SiChem
- Mol File:
- 1580501-97-8.mol
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(2E)-TCO-PNB ester Chemical Properties
- Boiling point:
- 433.9±45.0 °C(Predicted)
- Density
- 1.24±0.1 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- form
- Solid
- InChI
- InChI=1S/C15H17NO5/c17-15(20-13-6-4-2-1-3-5-7-13)21-14-10-8-12(9-11-14)16(18)19/h4,6,8-11,13H,1-3,5,7H2/b6-4+
- InChIKey
- XNTGBHHUEQUWSQ-GQCTYLIASA-N
- SMILES
- C(OC1=CC=C([N+]([O-])=O)C=C1)(=O)OC1CCCCCC=C1 |t:20|
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(2E)-TCO-PNB ester Usage And Synthesis
Uses
(2E)-TCO-PNB ester is a Click Amino Acid that can be used as a linker in the synthesis of PROTAC molecules. (2E)-TCO-PNB ester contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing a Tetrazine group.
References
[1] Natasha Bidesi, et al. Synthesis and radiolabeling of a polar [125 I]I-1,2,4,5-tetrazine. J Labelled Comp Radiopharm. 2023 Jan;66(1):22-30. DOI:10.1002/jlcr.4009
(2E)-TCO-PNB esterSupplier
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