L-CYCLOSERINE
L-CYCLOSERINE Basic information
- Product Name:
- L-CYCLOSERINE
- Synonyms:
-
- (S)-4-Aminoisoxazolidin-3-one
- Levocycloserine
- L-Cycloserine,99%
- L-Cycloserine,(S)-4-Amino-3-isoxazolidone
- cycloserinr
- 102.09
- Cycloserine Impurity 4 (L-Cycloserine)
- Cycloserine Impurity 4
- CAS:
- 339-72-0
- MF:
- C3H6N2O2
- MW:
- 102.09
- EINECS:
- 206-427-0
- Product Categories:
-
- NOVASTAT-W
- VARIOUSAMINE
- Mol File:
- 339-72-0.mol
L-CYCLOSERINE Chemical Properties
- Melting point:
- 147 °C
- Boiling point:
- 191.38°C (rough estimate)
- Density
- 1.278
- refractive index
- 1.5110 (estimate)
- storage temp.
- Keep in dark place,Sealed in dry,Store in freezer, under -20°C
- solubility
- H2O: soluble50mg/mg protein
- form
- White to off-white powder.
- pka
- 14.36±0.40(Predicted)
- color
- White to Off-White
- BRN
- 80799
- CAS DataBase Reference
- 339-72-0(CAS DataBase Reference)
MSDS
- Language:English Provider:SigmaAldrich
- Language:English Provider:ACROS
L-CYCLOSERINE Usage And Synthesis
Chemical Properties
WHITE GRANULAR POWDER
Uses
antibacterial, coccidiostat
Uses
L-Cycloserine is an irreversible inhibitor of 3-ketodihydrosphingosine synthetase.
Definition
ChEBI: A 4-amino-1,2-oxazolidin-3-one that has S configuration. An antibiotic isolated from Erwinia uredovora.
Biochem/physiol Actions
L-cycloserine is a potent inhibitor of serine palmitoyltransferase, the first step of sphingolipid synthesis.
Purification Methods
Purify cycloserine by recrystallisation from aqueous EtOH or MeOH or aqueous NH3/EtOH or isoPrOH. Also recrystallise it from aqueous ammoniacal solution at pH 10.5 (100mg/mL) by diluting with 5 volumes of isopropanol and then adjusting to pH 6 with acetic acid. An aqueous solution, buffered to pH 10 with Na2CO3, can be stored in a refrigerator for 1week without decomposition. UV: max at 226nm (A1cm 1% 4.02). The tartrate salt has m 165-166o (dec), 166-168o (dec), and [] D 24 -41o (c 0.7, H2O). [Stammer et al. J Am Chem Soc 79 3236 1959, UV: Kuehl J Am Chem Soc 77 2344 1955, Beilstein 27 III/IV 5549.]
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L-CYCLOSERINE(339-72-0)Related Product Information
- DL-CYCLOSERINE
- L-CYCLOSERINE
- D-Cycloserine
- TRYPTOSE SULFITE CYCLOSERINE AGAR,TRYPTOSE SULFITE CYCLOSERINE AGAR BASE
- ISOXAZOLIDINE
- AMINO ACID HYDROXAMATES GLYCINE HYDROXAMATE
- cycloserine diketopiperazine
- FMOC-D-CYCLOSERINE
- FMOC-L-CYCLOSERINE
- D-Cycloserine (1.08097)
- BOC-D-CYCLOSERINE
- TRYPTOSE SULFITE CYCLOSERINE SUPPLEMENT
- TRYPTOSE SULPHITE CYCLOSERINE AGAR (TSC)
- FMOC-D-CYCLOSERINE,
- FMOC-L-CYCLOPENTYLALYCINE, CYCLOSERINE(4-AMINO-3-ISOXAZOLIDINONE)
- BOC-L-CYCLOSERINE,
- TRYPTOSE SULPHITE CYCLOSERINE AGAR (TSC) (WITHOUT SUPPLEMENT , SEE LIST OF REAGENTS & SUPPLEMENTS 6-116CASE)
- CYCLOSERINE SELECTIVE SUPPLEMENT