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L-CYCLOSERINE

Basic information Safety Supplier Related

L-CYCLOSERINE Basic information

Product Name:
L-CYCLOSERINE
Synonyms:
  • (S)-4-Aminoisoxazolidin-3-one
  • Levocycloserine
  • L-Cycloserine,99%
  • L-Cycloserine,(S)-4-Amino-3-isoxazolidone
  • cycloserinr
  • 102.09
  • Cycloserine Impurity 4 (L-Cycloserine)
  • Cycloserine Impurity 4
CAS:
339-72-0
MF:
C3H6N2O2
MW:
102.09
EINECS:
206-427-0
Product Categories:
  • NOVASTAT-W
  • VARIOUSAMINE
Mol File:
339-72-0.mol
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L-CYCLOSERINE Chemical Properties

Melting point:
147 °C
Boiling point:
191.38°C (rough estimate)
Density 
1.278
refractive index 
1.5110 (estimate)
storage temp. 
Keep in dark place,Sealed in dry,Store in freezer, under -20°C
solubility 
H2O: soluble50mg/mg protein
form 
White to off-white powder.
pka
14.36±0.40(Predicted)
color 
White to Off-White
BRN 
80799
CAS DataBase Reference
339-72-0(CAS DataBase Reference)
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Safety Information

Hazard Codes 
Xn
Risk Statements 
5-20
Safety Statements 
38-36/37
WGK Germany 
2
RTECS 
NY2976000
10

MSDS

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L-CYCLOSERINE Usage And Synthesis

Chemical Properties

WHITE GRANULAR POWDER

Uses

antibacterial, coccidiostat

Uses

L-Cycloserine is an irreversible inhibitor of 3-ketodihydrosphingosine synthetase.

Definition

ChEBI: A 4-amino-1,2-oxazolidin-3-one that has S configuration. An antibiotic isolated from Erwinia uredovora.

Biochem/physiol Actions

L-cycloserine is a potent inhibitor of serine palmitoyltransferase, the first step of sphingolipid synthesis.

Purification Methods

Purify cycloserine by recrystallisation from aqueous EtOH or MeOH or aqueous NH3/EtOH or isoPrOH. Also recrystallise it from aqueous ammoniacal solution at pH 10.5 (100mg/mL) by diluting with 5 volumes of isopropanol and then adjusting to pH 6 with acetic acid. An aqueous solution, buffered to pH 10 with Na2CO3, can be stored in a refrigerator for 1week without decomposition. UV: max at 226nm (A1cm 1% 4.02). The tartrate salt has m 165-166o (dec), 166-168o (dec), and [] D 24 -41o (c 0.7, H2O). [Stammer et al. J Am Chem Soc 79 3236 1959, UV: Kuehl J Am Chem Soc 77 2344 1955, Beilstein 27 III/IV 5549.]

L-CYCLOSERINESupplier

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