N-NITROSO-L-PROLINE Chemical Properties

Melting point:

108-109°C

Boiling point:

262.71°C (rough estimate)

Density 

1.4054 (rough estimate)

refractive index 

1.4472 (estimate)

storage temp. 

-20°C Freezer

solubility 

Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly), Water (Sparingly)

pka

3.23±0.20(Predicted)

form 

Solid

color 

Pale Yellow to Brown

IARC

3 (Vol. 17, Sup 7) 1987

Safety Information

Toxicity

LD50 ipr-mus: 203 mg/kg JMCMAR 16,583,73

N-NITROSO-L-PROLINE Usage And Synthesis

Chemical Properties

Colourless Plates

Uses

A nitrosoamino acid with oncogenicity. The LD50 of a single ip dose given to Swiss-Webster mice is 203 +/- 22 mg / kg

Uses

A nitrosoamino acid with oncogenic activity. The LD50 of a single ip dose given to Swiss-Webster mice is 203 +/- 22 mg / kg.

Production Methods

There is no indication that nitrosoproline was made commercially. It has been reported in cured meats (e.g., bacon) at concentrations of 340–440 μg/kg. Both higher and lower levels in several cured products have been reported by several authors.

Definition

ChEBI: N-Nitrosoproline is a L-proline derivative.

Safety Profile

Poison by intraperitoneal route.Questionable carcinogen with experimental tumorigenicdata. Many nitroso compounds are carcinogens. Whenheated to decomposition it emits toxic fumes of NOx. Seealso NITROSO COMPOUNDS.

Carcinogenicity

Mice were given 0.1% NPRO in drinking water for 26 weeks, and no more lung adenomas were seen than in untreated controls at 38 weeks, showing a lack of carcinogenicity. In rats, higher doses (0.145%) in drinking water for 2 years showed no tumors that were not seen in untreated controls (174). IARC classified NPRO as not classifiable as to carcinogenicity to humans (Group 3).

N-NITROSO-L-PROLINE(7519-36-0)Related Product Information

• Hydroxyproline Assay Kit
• Ethyl 1-nitroso-L-proline
• 1-Nitroso-L-proline ethyl ester
• N-NITROSO-D-PROLINE
• (4R)-4-Hydroxy-1-nitroso-L-proline
• N-ETHYL-N-(2-HYDROXYETHYL)NITROSAMINE
• N-NITROSOPYRROLIDINE
• N-NITROSO-L-PROLINE
• N-NITROSOSARCOSINE