Minoxidil sulphate Chemical Properties

Melting point:

175-180°C

Density 

1.75±0.1 g/cm3(Predicted)

RTECS 

UV6260494

storage temp. 

-20°C

solubility 

Acetone (Slightly), DMSO (Slightly)

form 

White solid.

pka

-4.99±0.18(Predicted)

color 

White to Off-White

Stability:

Light Sensitive - Protect from Light, Store in Freezer

InChI

InChI=1S/C9H15N5O4S/c10-7-6-8(13-4-2-1-3-5-13)12-9(11)14(7)18-19(15,16)17/h6,10H,1-5H2,(H2,11,12)(H,15,16,17)

InChIKey

AGMYAAIWWVATKU-UHFFFAOYSA-N

SMILES

C1(N)N(OS(O)(=O)=O)C(=N)C=C(N2CCCCC2)N=1

CAS DataBase Reference

83701-22-8(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn,T+

Risk Statements 

22-36/37/38-26/27/28

Safety Statements 

26-36-45-36/37/39-22

WGK Germany 

3

MSDS

• Language:English Provider:SigmaAldrich

Minoxidil sulphate Usage And Synthesis

Application

Chemical Properties

White Crystalline Solid

Uses

specifically opens ATP-sensitive K channels, strong vascular smooth muscle relaxer, active minoxidil metabolite

Uses

Minoxidil sulfate (MXS) has been used as a drug agent to study its effects on alopecia in corticotropin-releasing factor over-expressing (CRF-OE) mice. It has also been used as a positive control in an assay for the culturing of rat vibrissa follicles.

Uses

A selective ATP-sensitive potassium channel opener. It is the active metabolite of minoxidil and is a potent (IC50=0.14) vascular smooth muscle relaxant

Biological Functions

Minoxidil sulfate is the active metabolite of Minoxidil and is a potent (IC50=0.14M) vascular smooth muscle relaxant. Minoxidil sulfate is a selective ATP-sensitive potassium channel opener.

Biochem/physiol Actions

Minoxidil sulfate (MXS) is an endogenous derivative of minoxidil. It possesses greater aqueous solubility and is a potent vasodilator. MXS has the potential to treat androgenic alopecia or male baldness.

in vitro

Minoxidil sulfate (1-100 μM; 2 hours) significantly reduces the permeability of bloode-brain tumor barrier (BTB) in a monolayer of RBMEC in a time-dependent manner, additionally,the effects of MS on transendothelial electrical resistance (TEER) is Transendothelial electrical resistance (TEER) at 2 h with high concentration.Minoxidil sulfate (0-100 μM; 0-4 hours) increases the RhoA activation in brain tumor tissue by 1 h and the highest level appears at 2 h, it also significantly induces transient PKB phosphorylation at Ser-473, without affecting total PKB levels. Addiotionally, LY294002 partly prevents the phosphorylation of PKB induced by MS.

Minoxidil sulphate(83701-22-8)Related Product Information

• FERROUS SULFATE
• SODIUM SULFATE
• Atropine sulfate
• Ferrous sulfate monohydrate
• Copper(II) sulfate
• Haloperidol
• Colistin sulfate
• Minoxidil
• D-Glucosamine sulfate
• 2,2,6,6-Tetramethylpiperidinooxy
• Potassium sulfate
• Ferric sulfate
• Ammonium sulfate
• Magnesium sulfate heptahydrate
• SULFATE STANDARD
• Albuterol sulfate
• Neomycin sulfate
• 2-ISOPROPYL-6-METHYL-4-PYRIMIDINOL