4-BROMO-BENZOTHIAZOL-5-YLAMINE Chemical Properties

Melting point:

115 °C

Boiling point:

359.3±22.0 °C(Predicted)

Density 

1.836±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

pka

0.50±0.10(Predicted)

Appearance

Light brown to gray Solid

Safety Information

Hazard Codes 

T

Risk Statements 

25

Safety Statements 

45

HS Code 

2934208090

4-BROMO-BENZOTHIAZOL-5-YLAMINE Usage And Synthesis

Synthesis

The general procedure for the synthesis of 5-amino-4-bromobenzothiazole from 1,3-benzothiazol-5-amine is as follows: a solution of bromine (2.3 g, 14.4 mmol) in trichloromethane (10 mL) was slowly added dropwise to a solution of benzo[d]thiazol-5-amine (2.1 g, 14.0 mmol) in trichloromethane (100 mL) at 10 °C. The reaction mixture was stirred continuously for 1 hour at room temperature. Subsequently, the reaction mixture was alkalized with saturated aqueous sodium carbonate solution (100 mL) and extracted with dichloromethane (3 x 30 mL). After combining the organic layers, they were dried with anhydrous sodium sulfate and concentrated under vacuum. The residue was purified by silica gel column chromatography (eluent ratio ethyl acetate/petroleum ether = 1:4) to give a final yellow solid 5-amino-4-bromobenzothiazole (2.3 g). The product was characterized by 1H NMR (300 MHz, CDCl3): δ 9.01 (s, 1H), 7.66 (d, 1H), 6.95 (d, 1H), 4.33 (s, 2H).

References

[1] Journal of the Chemical Society, 1965, p. 2248 - 2250
[2] Patent: US2009/118295, 2009, A1. Location in patent: Page/Page column 23-24
[3] Patent: WO2013/142266, 2013, A1. Location in patent: Paragraph 00507

4-BROMO-BENZOTHIAZOL-5-YLAMINE(769-19-7)Related Product Information

• 2-AMINO-4-BROMOBENZOTHIAZOLE
• 6-BROMO-BENZOTHIAZOL-2-YLAMINE
• 5-BROMO-BENZOTHIAZOL-2-YLAMINE
• 2-Amino-5-bromobenzothiazole
• 6-AMINO-7-BROMO-BENZOTHIAZOLE
• 4-BROMO-BENZOTHIAZOL-5-YLAMINE
• 1,3-BENZOTHIAZOL-5-AMINE