Basic information Safety Supplier Related
ChemicalBook >  Product Catalog >  Chemical Reagents >  Organic reagents >  Ethers >  COMBRETASTATIN A-4

COMBRETASTATIN A-4

Basic information Safety Supplier Related

COMBRETASTATIN A-4 Basic information

Product Name:
COMBRETASTATIN A-4
Synonyms:
  • Combretastatin A4 117048-59-6
  • Combretastatin A-4 - CAS 117048-59-6 - Calbiochem
  • CS-284
  • CRC 87-09
  • 2-methoxy-5-[(Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenol, Z
  • (Z)-2-Methoxy-5-[2-(3,4,5-trimethoxyphenyl)ethenyl]phenol,3,4,5-Trimethoxy-3hydroxy-4methoxy-(Z)-stilbene,CS-A4
  • Combrestatin A4( 2-Methoxy-5-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenol )
  • (Z)-2-Methoxy-5-(3,4,5-trimethoxystyryl)phenol ,98%
CAS:
117048-59-6
MF:
C18H20O5
MW:
316.35
Product Categories:
  • API
  • Anti-cancer & immunity
  • Inhibitors
  • Combretastatin
Mol File:
117048-59-6.mol
More
Less

COMBRETASTATIN A-4 Chemical Properties

Melting point:
84.5-85.5°C
Boiling point:
490.3±45.0 °C(Predicted)
Density 
1.184±0.06 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
DMSO: >10mg/mL
pka
9.65±0.10(Predicted)
form 
powder
color 
off-white
Merck 
14,2494
More
Less

Safety Information

Hazard Codes 
T
Risk Statements 
23/24/25-41
Safety Statements 
26-36/37-39-45
RIDADR 
UN 2811
WGK Germany 
2
HazardClass 
6.1
PackingGroup 
HS Code 
29095000
More
Less

COMBRETASTATIN A-4 Usage And Synthesis

Description

Combrestatin A4 (CA4) is a potent inhibitor of tubulin polymerization and displays strong inhibitory activity on tumor cell growth. Combrestatin A4 was shown to inhibit tumor growth in several cell lines including IMR32 (neuroblastoma), Hs746T (gastric carcinoma), CFPAC-1 (pancreatic carcinoma), and MCF-7 (breast cancer) with IC50 values of 2.16, 5.20, 3.46, and 18.47 nM, respectively. CA4 inhibits tubulin polymerization with an IC50 value of 2.2 μM.

Chemical Properties

Crystalline Powder

Uses

Combretastatin is a small organic molecule found in the bark of the African bush willow tree Combretum caffrum. Combretastatin-A4 Prodrug Induces Mitotic Catastrophe in Chronic Lymphocytic Leukemia Cell Line Independent of Caspase Activation and Poly(ADP-ribose) Polymerase Cleavage. A potent cytotoxic agent which strongly inhibits the polymerization of tubulin by binding to the colchicine site.

Uses

Combretastatin A4 has been used:

  • as an anti-tubulin agent to determine the effects of isocitrate dehydrogenases (IDH1 and IDH2) proteins in G2/M phase
  • to evaluate the anti-proliferative and pro-apoptotic properties of biphenyl CA4 derivatives in both 2D and 3D cancerous and non-cancerous cell models
  • as a microtubule inhibitor to study its effects on motility of Ascaris suum L3 larvae

Definition

ChEBI: Combretastatin A4 is a stilbenoid.

General Description

Combretastatin A4 belong to the class of colchicinoids compounds.

Biological Activity

Antitumor, antiangiogenic and antimetastatic agent, in vitro and in vivo . Acts by inhibiting tubulin polymerization (IC 50 = 2-3 μ M).

Biochem/physiol Actions

Combretastatin A4 is a vascular disrupting agent (VDA) that targets tumor vasculature to inhibit angiogenesis. It inhibits tubulin polymerization at the colchicine-binding site of beta-tubulin. It has antitumor activity by inhibiting AKT function in human gastric cells. The inhibited AKT activation causes decreased cell proliferation, cell cycle arrest, and reduced in vitro migration/invasiveness and in vivo metastatic ability. Combretastatin A4 is a natural stilbenoid phenol.

Anticancer Research

It is a stilbenoid compound and the active among all combretastatins isolated fromthe bark of Combretum caffrum and is used for colon, lung, and leukemia cancertherapy (Shoeb 2006).

COMBRETASTATIN A-4 Preparation Products And Raw materials

Raw materials

COMBRETASTATIN A-4Supplier

Guangzhou Isun Pharmaceutical Co., Ltd Gold
Tel
020-39119399 18927568969
Email
isunpharm@qq.com
Hangzhou Great Forest Biomedical Ltd. Gold
Tel
0571-28313180 17767135330
Email
info@great-forest.com
Chengdu Forest Science and Technology Development Co., Ltd. Gold
Tel
18030648795 18030648795
Email
sales@cdforestchem.com
Shanghai Boyle Chemical Co., Ltd.
Tel
Email
sales@boylechem.com
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Email
jkinfo@jkchemical.com