SPARSOMYCIN Chemical Properties

Melting point:

208-209° (dec)

alpha 

D25 +69° (c = 0.5 in water)

Density 

1.3893 (rough estimate)

refractive index 

1.6390 (estimate)

storage temp. 

2-8°C

solubility 

DMF: soluble,DMSO: soluble,Ethanol: soluble,Methanol: soluble

form 

A solid

pka

8.67 in water, 9.05 in 40% ethanol

color 

White to off-white

Safety Information

Hazard Codes 

T+

Risk Statements 

28

Safety Statements 

28-36/37-45

RIDADR 

UN 2811 6.1/PG 2

RTECS 

WG5850000

Toxicity

LD50 in dogs, rats, mice (mg/kg): 0.5-1.0, 2.25, 4.32 i.v. (Ottenheijm, 1986); LD50 i.p. in mice: 2.4 mg/kg (Owen)

SPARSOMYCIN Usage And Synthesis

Description

Sparsomycin is a bacterial metabolite and a nucleoside analog of uracil that has been found in S. sparsogenes and has diverse biological activities. It is active against KB carcinoma cells, Gram-positive and Gram-negative bacteria, and fungi. Sparsomycin is an inhibitor of peptidyl transferase that interferes with tRNA binding to the A-site of the peptidyl transfer center and increases the binding of peptidyl-tRNA to the P-site. It inhibits protein synthesis in bacteria, archaea, and eukaryotes. Sparsomycin reduces tumor growth in a P388 mouse leukemia model and in a Walker 256 carcinosarcoma rat model.

Uses

Research tool for studying protein biosynthesis.

Uses

Sparsomycin is an antibiotic that binds to active site and exit tunnel hydrophobic crevices of peptidyltransferase center of Haloarcula marismortui large ribosomal subunit.

References

[1] H C OTTENHEIJM. Chemical and biological aspects of sparsomycin, an antibiotic from Streptomyces.[J]. Progress in medicinal chemistry, 1986, 23: 219-268. DOI: 10.1016/s0079-6468(08)70344-8
[2] E. LAZARO . Chemical, biochemical and genetic endeavours characterizing the interaction of sparsomycin with the ribosome[J]. Biochimie, 1991, 73 7: Pages 1137-1143. DOI: 10.1016/0300-9084(91)90157-v
[3] D J MASON  R M S  A DIETZ. Actinospectacin, a new antibiotic. I. Discovery and biological properties.[J]. Antibiotics & chemotherapy (Northfield, Ill.), 1961, 11: 118-122.
[4] Z ZYLICZ. In vivo antitumor activity of sparsomycin and its analogues in eight murine tumor models.[J]. Investigational New Drugs, 1988, 6 4: 285-292. DOI: 10.1007/bf00173646

SPARSOMYCIN(1404-64-4)Related Product Information

• MMTS
• 5,6-DIMETHYLURACIL
• SPARSOMYCIN
• FORTIMICIN