Gadoteridol Chemical Properties

Melting point:

188-193 °C

storage temp. 

Store at -20°C

solubility 

PBS (pH 7.2): 10 mg/ml

form 

A solid

color 

White to off-white

Appearance

dark green powder

InChI

InChI=1S/C17H31N4O7.Gd/c1-14(22)10-18-2-4-19(11-15(23)24)6-8-21(13-17(27)28)9-7-20(5-3-18)12-16(25)26;/h14H,2-13H2,1H3,(H,23,24)(H,25,26)(H,27,28);/q-1;+4/p-3

InChIKey

JOJFJDKAWWEUPD-UHFFFAOYSA-K

SMILES

CC1CN23CCN45CCN67CCN8(CC2)CC(=O)[O-][Gd+3]3486([O-]C(=O)C5)([O-]C(=O)C7)O1

Safety Information

Hazard Codes 

Xn,T,N,Xi

Risk Statements 

22-25-36-50-43-41

Safety Statements 

45-26-61-36/37-39

HS Code 

2942000000

Hazardous Substances Data

120066-54-8(Hazardous Substances Data)

Gadoteridol Usage And Synthesis

Description

Indocyanine Green (ICG, IC Green, Foxgreen) is a negatively charged tricarbocyanine dye widely used for imaging and flow cytometry due to its low toxicity and near-infrared fluorescence emission.

ICG has an absorption maximum at 787 nm with slight absorption in the visible range and a fluorescence emission maximum at 819 nm. The minimal light scattering and low autofluorescence in this spectral range result in a significantly reduced background and improved signal-to-noise ratios, thereby enhancing detection sensitivity.

ICG maleimide is a thiol-reactive dye for labeling of protein SH groups, and it can be used to attach ICG fluorophore to proteins and peptides containing cysteine residues, as well as to other thiolated molecules (such as thiol-containing oligonucleotides). Cystines should be reduced with TCEP (tris-carboxyethylphosphine) or with another appropriate reductant prior to the labeling.

Uses

Gadoteridol is used as an MRI contrast chelating agent.

Uses

Diagnostic aid (paramagnetic).

Definition

ChEBI: A non-ionic gadolinium chelate having a macrocyclic tetraamine framework. It is used as a paramagnetic contrast agent in magnetic resonance imaging (MRI).

brand name

Prohance (Bracco).

General Description

Gadoteridol is a nonionicclear, colorless to slightly yellow, gadolinium-based contrastagent indicated to visualize lesions with abnormal vascularityin the CNS, head, and neck. It is a hypertonic solutionwith an osmolality of 2.2 times that of plasma. Clinical enhancementof images occurs primarily when using T1-weighted sequences.

Abs/Em Maxima

787/819 nm

Fluoresene quantum yield

0.09

Extinction Coefficient

232000

Gadoteridol(120066-54-8)Related Product Information

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