ESR1 antibody Usage And Synthesis

Applications

Western Blot, Immunofluorescent Staining, Immunohistochemistry, flow cytometry, immunoprecipitation.

Immunogen

Recombinant human ER-alpha.

Background

Estrogen receptors α (ERα, ER; NR3A1) is a member of the steroid hormone receptor family.  ERα is a ligand-activated transcription factor.  ERα contain DNA binding and ligand binding domains.   ERα is expressed in a wide variety of tissues, including ovary, uterus, breast, prostate, testis, epididymis, bones, bladder, kidney, heart, vessel wall, pituitary gland and hypothalamus. ER plays a variety of important roles in the maintenance of the reproductive, cardiovascular, musculoskeletal and central nervous systems.   The natural ligand for ER is 17β-estradiol, the classical estrogenic compound.  The binding of estrogen to ER induces a conformational change and triggers a cascade of events, including dissociation from heat shock proteins, receptor dimerization, phosphorylation and the association of the hormone activated receptor with specific regulatory elements in target genes.

ESR1 antibody()Related Product Information

• Mouse Monoclonal GKAP Antibody
• Mouse Monoclonal TNFRSF11B Antibody
• CDK5 antibody
• HIF1A antibody
• MMP 1 antibody
• PRKDC antibody
• BMPR2 antibody
• MAP2K4 antibody
• CRK antibody
• CRTC3 Antibody