MCM7 antibody Usage And Synthesis

Source

Rabbit

Applications

MCM7 antibody has been tested by ELISA and Western blot analysis to assure specificity and reactivity.

Reactivity

Human;Mouse;Rat;Hamster;Monkey

Immunogen

Anti-human MCM7 mAb, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human MCM7 protein 1-414 amino acids purified from E. coli.

Background

MCM7 is a highly conserved mini-chromosome maintenance protein (MCM) vital for eukaryotic genome replication initiation. The MCM proteins form a hexameric protein complex which is a key component of the pre-replication complex (pre_RC) which takes part in replication forks formation and in DNA replication related proteins recruitment. The MCM complex is comprised of MCM2, 4, 6 and 7 proteins and possesses DNA helicase activity, such as DNA unwinding. 

References

[1] Lei, M. and Tye, B.K. (2001) J Cell Sci 114, 1447-54.
[2] Lygerou, Z. and Nurse, P. (2000) Science 290, 2271-3.
[3] Forsburg, S.L. (2004) Microbiol Mol Biol Rev 68, 109-31.
[4] Tye, B.K. and Sawyer, S. (2000) J Biol Chem 275, 34833-6.
[5] Labib, K. et al. (2000) Science 288, 1643-7.
[6] Charych, D.H. et al. (2008) J Cell Biochem 104, 1075-86.
[7] Masai, H. et al. (2006) J Biol Chem 281, 39249-61.
[8] Lin, D.I. et al. (2008) Proc Natl Acad Sci USA 105, 8079-84.
[9] Tsuji, T. et al. (2006) Mol Biol Cell 17, 4459-472.
[10] Bailis, J.M. et al. (2008) Mol Cell Biol 28, 1724-38.

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