RAD50 Antibody Usage And Synthesis

Source

Rabbit

Reactivity

Human;Monkey

Background

The DNA repair protein Rad50 is a member of the structural maintenance of chromosomes family and plays an important role in cell cycle checkpoint signaling and double-strand break repair in response to DNA damage. Rad50 forms a complex with Mre11 and NBS1 that becomes activated in response to DNA damage. In normal human cells, the MRN complex acts to tether linear DNA molecules, providing a flexible link between DNA ends. Genomic instability and cancer have been shown to develop in cells with genetic mutations affecting the proteins in the MRN complex. ATM-dependent phosphorylation of Rad50 at Ser635 in response to DNA damage is important in regulating downstream signaling, DNA repair, and checkpoint control.

References

[1] de Jager, M. et al. (2001) Mol. Cell 8, 1129-35.
[2] Elledge, S.J. (1996) Science 274, 1664-1672.
[3] Lee, J.H. and Lim, D.S. (2006) FEBS J. 273, 1630-36.
[4] Teng, S.C. et al. (2006) J Mol Histol 37, 293-9.
[5] Gatei, M. et al. (2011) J Biol Chem 286, 31542-56.

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