E3 ligase Ligand-Linker Conjugates 50
E3 ligase Ligand-Linker Conjugates 50 Basic information
- Product Name:
- E3 ligase Ligand-Linker Conjugates 50
- Synonyms:
-
- E3 ligase Ligand-Linker Conjugates 50
- Cereblon Ligand-Linker Conjugates 13
- Pomalidomide-PEG1-C2-N3
- 4-((2-(2-azidoethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
- 1H-Isoindole-1,3(2H)-dione, 4-[[2-(2-azidoethoxy)ethyl]amino]-2-(2,6-dioxo-3-piperidinyl), 4-((2-(2-Azidoethoxy)ethyl]amino]-2-(2,6-dioxopiperidin-3-yl]isoindoline-1,3-dione, 4-[[2-(2-Azidoethoxy)ethyl]amino]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione
- Poma-PEG1-N3
- CAS:
- 2271036-44-1
- MF:
- C17H18N6O5
- MW:
- 386.37
- Mol File:
- 2271036-44-1.mol
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E3 ligase Ligand-Linker Conjugates 50 Chemical Properties
- storage temp.
- -20°C, stored under nitrogen
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E3 ligase Ligand-Linker Conjugates 50 Usage And Synthesis
Biological Activity
Pomalidomide-PEG1-C2-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 1-unit PEG linker used in PROTAC technology. Pomalidomide-PEG1-C2-N3 can be used to design a selective CDK6 PROTAC degrader CP-10. CP-10 induces the degradation of CDK6 with an DC50 of 2.1 nM[1].
storage
Store at -20°C
References
[1]. Su S, et al. Potent and Preferential Degradation of CDK6 via Proteolysis Targeting Chimera Degraders. J Med Chem. 2019 Aug 2.
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E3 ligase Ligand-Linker Conjugates 50(2271036-44-1)Related Product Information
- Pomalidomide-PEG4-CO2H
- E3 Ligase Ligand-Linker Conjugates 1
- POMALIDOMIDE-PEG2-CO2H
- Pomalidomide-PEG1-azide
- Pomalidomide-PEG5-CO2H
- POMALIDOMIDE-PEG1-CO2H
- Pomalidomide-O-C4-NH2
- Propanoic acid, 3-[[17-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-3,6,9,12,15-pentaoxaheptadec-1-yl]oxy]-
- Pomalidomide-PEG3-N3
- Pomalidomide-PEG6-butyl iodide
- E3 Ligase Ligand-Linker Conjugates 21
- E3 ligase Ligand-Linker Conjugates 13
- E3 Ligase Ligand-Linker Conjugates 25 Trifluoroacetate
- E3 ligase Ligand-Linker Conjugates 4
- E3 ligase Ligand-Linker Conjugates 6
- E3 Ligase Ligand-Linker Conjugates 19
- E3 ligase Ligand-Linker Conjugates 7 Free Base
- E3 Ligase Ligand-Linker Conjugates 22