Basic information Safety Supplier Related

E3 ligase Ligand-Linker Conjugates 50

Basic information Safety Supplier Related

E3 ligase Ligand-Linker Conjugates 50 Basic information

Product Name:
E3 ligase Ligand-Linker Conjugates 50
Synonyms:
  • E3 ligase Ligand-Linker Conjugates 50
  • Cereblon Ligand-Linker Conjugates 13
  • Pomalidomide-PEG1-C2-N3
  • 4-((2-(2-azidoethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
  • 1H-Isoindole-1,3(2H)-dione, 4-[[2-(2-azidoethoxy)ethyl]amino]-2-(2,6-dioxo-3-piperidinyl), 4-((2-(2-Azidoethoxy)ethyl]amino]-2-(2,6-dioxopiperidin-3-yl]isoindoline-1,3-dione, 4-[[2-(2-Azidoethoxy)ethyl]amino]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione
  • Poma-PEG1-N3
  • 1H-Isoindole-1,3(2H)-dione, 4-[[2-(2-azidoethoxy)ethyl]amino]-2-(2,6-dioxo-3-piperidinyl)-
CAS:
2271036-44-1
MF:
C17H18N6O5
MW:
386.37
Mol File:
2271036-44-1.mol
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E3 ligase Ligand-Linker Conjugates 50 Chemical Properties

storage temp. 
-20°C, stored under nitrogen
form 
Solid
color 
Light yellow to yellow
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E3 ligase Ligand-Linker Conjugates 50 Usage And Synthesis

Biological Activity

Pomalidomide-PEG1-C2-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 1-unit PEG linker used in PROTAC technology. Pomalidomide-PEG1-C2-N3 can be used to design a selective CDK6 PROTAC degrader CP-10. CP-10 induces the degradation of CDK6 with an DC50 of 2.1 nM[1].

storage

Store at -20°C

References

[1]. Su S, et al. Potent and Preferential Degradation of CDK6 via Proteolysis Targeting Chimera Degraders. J Med Chem. 2019 Aug 2.

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