PIPERAZINE-2-CARBOXYLIC ACID Chemical Properties

Melting point:

265 °C (dec.)(lit.)

pka

pKa1 1.5,pKa2 5.41,pKa3 9.53（22℃）

CAS DataBase Reference

133525-05-0(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

Hazard Note 

Irritant

PIPERAZINE-2-CARBOXYLIC ACID Usage And Synthesis

Application

Piperazine-2-carboxylic acid dihydrochloride can be used as a pharmaceutical synthesis intermediate. The reaction proceeds as follows: Piperazine-2-carboxylic acid dihydrochloride (2 g, 9.8 mmol) and (Boc)₂O (8.6 g, 39.4 mmol) are dissolved in THF (40 mL) and water (40 mL). Sodium bicarbonate (8.31 g, 79.8 mmol) is added. The reaction mixture is magnetically stirred at room temperature for 4 hours, then ethyl acetate is added. The mixture is separated using a separatory funnel. The separated organic phase is washed with saturated brine, dried over anhydrous sodium sulfate, concentrated under reduced pressure, and then separated by silica gel column chromatography. 2.5 g of 1,4-di-tert-butoxycarbonylpiperazine-2-carboxylic acid (13-2) was obtained after purification, with a yield of 78%. LC-MS (ESI): m/z (M+1) 331.2.

PIPERAZINE-2-CARBOXYLIC ACID(133525-05-0)Related Product Information

• Piperazine-2-carboxylic acid dihydrochloride
• 1-(TERT-BUTOXYCARBONYL)-4-[(9H-FLUOREN-9-YLMETHOXY)CARBONYL]-2-PIPERAZINECARBOXYLIC ACID
• Ethyl 1,4-dimethylpiperazine-2-carboxylate
• PIPERAZINE-2-CARBOXYLIC ACID
• Piperazine-2-carboxylic acid methyl ester dihydrochloride
• Ethyl 1,4-dibenzylpiperazine-2-carboxylate
• (R)-CPP
• 2-Piperazinecarboxylic acid dihydrochloride
• 2-PHENYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
• 2-ETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
• 1-(2-CARBOXY-PHENYL)-PIPERAZINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER
• 1-N-BOC-2-PIPERAZINECARBOXYLIC ACID METHYL ESTER
• (S)-1-Boc-3-methylpiperazine
• 1-Boc-4-(2-pyridinyl)-piperazine
• 2-PIPERAZINECARBOXYLIC ACID, (2R)-
• (R)-1-Boc-3-methylpiperazine
• 2-PIPERAZINECARBOXYLIC ACID, (2S)-
• 4-(6,7-Dimethoxyquinazolin-4-yl)-1-piperazinecarboxylic acid 2-hydroxy-2-methylpropyl ester