2-CHLOROLEPIDINE Chemical Properties

Melting point:

55-58 °C(lit.)

Boiling point:

296 °C(lit.)

Density 

1.1810 (rough estimate)

refractive index 

1.6224 (estimate)

Flash point:

296°C

storage temp. 

Inert atmosphere,Room Temperature

form 

powder to crystal

pka

0.98±0.50(Predicted)

color 

White to Almost white

BRN 

118333

CAS DataBase Reference

634-47-9(CAS DataBase Reference)

NIST Chemistry Reference

Quinoline, 2-chloro-4-methyl-(634-47-9)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-37/39-36-24/25

WGK Germany 

3

HS Code 

29334900

MSDS

• Language:English Provider:SigmaAldrich

2-CHLOROLEPIDINE Usage And Synthesis

Description

4-Methyl-2-chloro-quinoline is an organic intermediate. It has been reported that it can be used to prepare graphite electrodes based on CrO-FeO-PbO and quinoline modified and a modified vermiculite adsorbent for the adsorption and removal of benzene in chemical wastewater.

Preparation

The mixture of 2-hydroxy-4-methylquinoline and phosphorus oxychloride was heated to 80-85°C. After the solid was completely dissolved, the mixture was poured into ice water, the mixture was extracted with ether, and the ether extract was distilled out of ether. Afterwards, carry out vacuum distillation, collect 132-135 ℃ (0.4kPa) fraction, namely 2-chloro-4-methylquinoline. For further purification, petroleum ether (boiling point 40-50°C) can be used for recrystallization, and the yield is 86%-89%.

Chemical Properties

white to light yellow crystal powder

Uses

2-Chloro-4-methyl-quinoline is a useful synthetic intermediate. It is an intermediate used to synthesize 4-Methyl-2-(1-piperidinyl)-quinoline (M320715) which is a potent inhibitor of TRPC4 channels, responsible for various stimulation, muscle response due to interaction with the environment. 2-Chloro-4-methyl-quinoline is also considered as a cyanine dye.

Synthesis Reference(s)

Journal of the American Chemical Society, 63, p. 2367, 1941 DOI: 10.1021/ja01854a016
Organic Syntheses, Coll. Vol. 3, p. 194, 1955

2-CHLOROLEPIDINE(634-47-9)Related Product Information

• 5-Chloroquinaldine
• 4-CHLORO-2-METHYLQUINOLINE
• 7-Chloro-2-methylquinoline
• 2-CHLOROLEPIDINE
• 2-CHLOROQUINOLINE-4-CARBOXYLIC ACID
• 6-BROMO-2-CHLOROQUINOLINE-4-CARBOXYLIC ACID, 97
• 4-methylquinoline
• 2-Chloroquinoline
• IFLAB-BB F0016-0970
• METHYL 6-BROMO-2-CHLOROQUINOLINE-4-CARBOXYLATE
• 2-CHLORO-4,6-DIMETHYL-QUINOLINE
• 6-BROMO-2-CHLOROQUINOLINE-4-CARBONYL CHLORIDE
• 2,6-DIMETHOXY-4-METHYLQUINOLINE
• 6-CHLOROLEPIDINE
• 2-CHLORO-4-PHENYLQUINOLINE
• 6-BROMO-2-CHLORO-4-PHENYLQUINOLINE
• 2-CHLORO-4,7-DIMETHYLQUINOLINE
• N,N-Diethyl-2-chloroquinoline-4-carboxamide