Fotemustine Chemical Properties

Melting point:

85°

Density 

1.37±0.1 g/cm3(Predicted)

storage temp. 

2-8°C

solubility 

H2O: ≥1mg/mL

form 

powder

pka

9.47±0.46(Predicted)

color 

light yellow

CAS DataBase Reference

92118-27-9(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn

Risk Statements 

40

Safety Statements 

36/37

WGK Germany 

3

Hazardous Substances Data

92118-27-9(Hazardous Substances Data)

Fotemustine Usage And Synthesis

Description

Fotemustine is a new nitrosourea reportedly effective in the treatment of disseminated malignant melanoma, with only mild hematological toxicity. Response rate is generally lower in patients with colonic, breast, head and neck cancer.

Originator

Servier (France)

Uses

Fotemustine is used in patients malignant gliomas to improve the efficacy of radiotherapy. Used in the treatment of glioblastomas.

Definition

ChEBI: Diethyl (1-{[(2-chloroethyl)(nitroso)carbamoyl]amino}ethyl)phosphonate is a member of the class of N-nitrosoureas that is ethyl diethylphosphonate in the hydrogen at position 1 of the ethyl group attached to the phosphorus has been replaced by a [(2-chloroethyl)(nitroso)carbamoyl]amino group. It is an organic phosphonate, a member of N-nitrosoureas and an organochlorine compound.

brand name

Muphoran

Fotemustine(92118-27-9)Related Product Information

• Triethyl phosphite
• Bendamustine hydrochloride
• Diethyl phosphite
• DIETHYL ETHYLPHOSPHONATE
• Triethyl phosphate
• Bendamustine
• Ethyl dichlorophosphate
• Tris(2-chloroethyl) phosphate
• N-NITROSO-N-ETHYLUREA
• N-Nitrocarbamide
• 1-Methyl-1-nitrosourea
• Chlorine
• ETHYLPHOSPHONIC ACID
• DIETHYL PHOSPHATE
• Chlormethine
• (AMINOMETHYL)PHOSPHONIC ACID HYDROCHLORIDE
• DIETHYL N-FORMYL-AMINOMETHYL PHOSPHONATE
• 1-(2-chloroethyl)-1-nitrosourea