Creatine phosphate disodium salt Chemical Properties

Density 

1.784 at 20℃

vapor pressure 

0.025Pa at 20-50℃

storage temp. 

Inert atmosphere,2-8°C

solubility 

H₂O: 0.1 g/mL, clear, colorless

form 

Powder

color 

White

PH

pH : 8.3 (20% in water)

Water Solubility 

soluble

InChI

InChI=1S/C4H10N3O5P.Na.H/c1-7(2-3(8)9)4(5)6-13(10,11)12;;/h2H2,1H3,(H,8,9)(H4,5,6,10,11,12);;

InChIKey

HUWYWJSJJDCZRQ-UHFFFAOYSA-L

SMILES

C(=N)(NP(O)(O)=O)N(C)CC(=O)O.[NaH]

LogP

-1.17 at 22℃ and pH7

Surface tension

68.63mN/m at 1.034g/L and 20℃

CAS DataBase Reference

922-32-7(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn

Risk Statements 

20/21/22-36/37/38

Safety Statements 

22-24/25-36-26

WGK Germany 

3

F 

10

HS Code 

29252900

MSDS

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Creatine phosphate disodium salt Usage And Synthesis

Description

Creatine phosphate belongs to the human body and is the most important type of energy supplier. It can provide energy support for various tissues and organs. In human brain, kidney, cardiac muscle and skeletal muscle, 80% of the energy source is creatine phosphate. In humans, the synthesis of creatine phosphate begins in the kidney organs. A guanidinic acid is formed from arginine and glycine, and then creatine is formed through methylation in the liver. Finally, it is phosphorylated in various cellular tissues. And creatine phosphate is formed. Creatine phosphate disodium salt is a commercial creatine phosphate drug, which has become more and more widely used in acute myocardial infarction in recent years, and has achieved good results.

Uses

Creatine phosphate disodium salt is a white needle-like crystalline powder that is easily soluble in water. In medicine, it can protect the heart muscle by injecting creatine phosphate disodium salt, and can also be used to treat myocardial abnormalities in the ischemic state. creatine phosphate plays an important role in energy metabolism during muscle contraction[3]. The use of creatine phosphate is generally by intravenous injection. Phosphocreatine disodium salt exists as creatine phosphate after entering the body.

Chemical Properties

white powder

Uses

Creatine Phosphate Disodium Salt is an impurity of Creatine(C781483). Creatine can be used in biological study of high fat diets with different ketogenic ratios on hippocampal accumulation of creatine.

storage

Store at -20°C

Purification Methods

The salt first appears as oily droplets which slowly settle and crystallise. After 12hours the supernatant is clear. Stirring and scratching the flask containing the filtrate brings out additional crystals (0.3-1g) if the salt is kept at 20o for 12hours. Filter it off at room temperature, wash with 3 x 5mL of ice-cold 90% EtOH, then 5mL of absolute EtOH and dry it in a vacuum desiccator (Drierite or CaCl2) for 16-30hours. The hexahydrate (plates) is converted to the tetrahydrate salt (needles) in a vacuum at -10o. [Ennor & Stocken Biochemical Preparations 5 9 1957, Biochem J 43 190 1958, Beilstein 4 III 1170, 4 IV 2425.]

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