4-Fluorophenol Chemical Properties

Melting point:

43-46 °C (lit.)

Boiling point:

185 °C (lit.)

Density 

1.22

Flash point:

155 °F

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

solubility 

80g/l

form 

Crystalline Solid

pka

9.89(at 25℃)

color 

Yellow-beige to pink

PH

5.4 (H2O, 20℃)(saturated aqueous solution)

Water Solubility 

50 g/L

BRN 

1362752

Stability:

Stable. Flammable. Incompatible with strong oxidizing agents.

Dissociation constant

0 at 27℃

CAS DataBase Reference

371-41-5(CAS DataBase Reference)

NIST Chemistry Reference

Phenol, 4-fluoro-(371-41-5)

EPA Substance Registry System

Phenol, 4-fluoro- (371-41-5)

Safety Information

Hazard Codes 

Xn,C,T,F+

Risk Statements 

20/21/22-36/37/38-52/53

Safety Statements 

26-37/39-61-36

RIDADR 

UN 2928 6.1/PG 2

WGK Germany 

1

RTECS 

SL4550000

F 

10-23

Hazard Note 

Corrosive/Harmful

TSCA 

T

HazardClass 

6.1

PackingGroup 

III

HS Code 

29081000

MSDS

• Language:English Provider:4-Fluorophenol
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

4-Fluorophenol Usage And Synthesis

Chemical Properties

white to light yellow crystal powder

Uses

4-Fluorophenol is a fluorinated phenolic compound with various applications as a starting reagent for synthesizing pharmaceuticals. It is a widely used intermediate in the industrial production of several drugs, including cisapride and Sabeluzole by Janssen, Sorbinil by Pfizer, and Progabide by Synthelabo.

Definition

ChEBI: 4-fluorophenol is a fluorophenol that is phenol in which the hydrogen para- to the hydroxy group has been replaced by a fluorine. It is a fluorophenol and a member of monofluorobenzenes. It is used as an intermediate in the production of liquid crystals.

Preparation

Acetyl hypofluorite also will fluoro-demetallate benzene derivatives, for example mercury derivatives of phenol gave 4-fluorophenol.

Synthesis Reference(s)

Tetrahedron, 52, p. 23, 1996 DOI: 10.1016/0040-4020(95)00867-8

Hazard

Irritant.

4-Fluorophenol(371-41-5)Related Product Information

• 2-Phenylphenol
• Acetaminophen
• 4-Fluorobenzonitrile
• 4-tert-Butylphenol
• 4-Chlorophenol
• SODIUM PHENOLATE TRIHYDRATE
• 4-Aminophenol
• p-Cresol
• 2,6-Difluorophenol
• 4-Nitrophenol
• 3,4,5-Trifluorophenol
• Pentafluorophenol
• 2-Bromo-4-fluorophenol 97%,2-Bromo-4-fluorophenol,98+%
• 2-Bromo-4-fluoroanisole
• 2-Chloro-4-fluorophenol 99%
• 4-Fluorophenoxyacetic acid
• 2,4-Difluorophenol
• 1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone