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ISOVALERAMIDE

Basic information Safety Supplier Related

ISOVALERAMIDE Basic information

Product Name:
ISOVALERAMIDE
Synonyms:
  • ISOVALERAMIDE
  • beta-Methylbutyramide
  • isopentanamide
  • Isovaleric amide
  • isovalericacidamide
  • 3-METHYLBUTYRAMIDE
  • 3-METHYLBUTANAMIDE
  • ISOVALERAMIDE 98%
CAS:
541-46-8
MF:
C5H11NO
MW:
101.15
EINECS:
208-781-1
Product Categories:
  • RETROVIR
Mol File:
541-46-8.mol
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ISOVALERAMIDE Chemical Properties

Melting point:
135 °C
Boiling point:
232°C
Density 
0.965
refractive index 
1.4367 (estimate)
Flash point:
232°C
storage temp. 
Sealed in dry,Room Temperature
solubility 
DMSO:135.0(Max Conc. mg/mL);1334.66(Max Conc. mM)
Ethanol:20.0(Max Conc. mg/mL);197.73(Max Conc. mM)
Water:20.0(Max Conc. mg/mL);197.73(Max Conc. mM)
form 
White Crystalline flakes
pka
16.72±0.40(Predicted)
color 
White to off-white
Merck 
14,5230
BRN 
1740789
InChI
InChI=1S/C5H11NO/c1-4(2)3-5(6)7/h4H,3H2,1-2H3,(H2,6,7)
InChIKey
SANOUVWGPVYVAV-UHFFFAOYSA-N
SMILES
C(N)(=O)CC(C)C
CAS DataBase Reference
541-46-8(CAS DataBase Reference)
EPA Substance Registry System
Butanamide, 3-methyl- (541-46-8)
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Safety Information

Hazard Codes 
Xi
Safety Statements 
22-24/25
RTECS 
EJ3650000
TSCA 
Yes
HS Code 
2924190090

MSDS

  • Language:English Provider:ALFA
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ISOVALERAMIDE Usage And Synthesis

Uses

RT transferase inhibitor, antiviral

in vivo

Isovaleramide (100 mg/kg, p.o., a single dose at 4-hour following fasting) evidences a 90% index protection against the maximal electroshock seizure in mice[1].
Isovaleramide (10 and 20 mg/kg, i.v.,every 12 h for 48 h) reduces the mortality rate, attenuates the pathological damage of kidney tissues in EG-poisoned rats and down-regulates the expression of serum biomarkers of AKI[2].
Isovaleramide (100 mg/kg; p.o.) shows a 90% index protection against the maximal electroshock (MES)-induced seizure in mice, comparable to Sodium phenytoin (HY-B0448A)[4].

Animal Model:ICR mice with electric shock induced seizures[1]
Dosage:100 mg/kg
Administration:p.o., a single dose at 4-hour following fasting
Result:Evidenced a 90% index protection against the maximal electroshock seizure in mice.
Animal Model:Rat model of EG poisoning[1]
Dosage:10 and 20 mg/kg
Administration:i.v.,every 12 h for 48 h
Result:Effectively reduced the mortality of EG-poisoned rats, and this effect may be dose-dependent.

ISOVALERAMIDESupplier

Nantong Huakang Medicine Technology Co.,Ltd. Gold
Tel
18912220755
Email
249125764@qq.com
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Email
jkinfo@jkchemical.com
INTATRADE GmbH
Tel
+49 3493/605464
Email
sales@intatrade.de
Alfa Aesar
Tel
400-6106006
Email
saleschina@alfa-asia.com
Energy Chemical
Tel
021-021-58432009 400-005-6266
Email
sales8178@energy-chemical.com
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