L-Serinamide hydrochloride Chemical Properties

Melting point:

185-188 °C(lit.)

alpha 

14 º (c=1, H2O)

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

form 

Crystals or Crystalline Powder

color 

Red to purple

optical activity

[α]20/D +14°, c = 1 in H2O

InChI

InChI=1/C3H8N2O2.ClH/c4-2(1-6)3(5)7;/h2,6H,1,4H2,(H2,5,7);1H/t2-;/s3

InChIKey

VURWDDZIWBGXCK-NNUCSGGJNA-N

SMILES

[C@H](N)(CO)C(=O)N.Cl |&1:0,r|

CAS DataBase Reference

65414-74-6(CAS DataBase Reference)

Safety Information

Safety Statements 

24/25

WGK Germany 

3

HS Code 

29241990

MSDS

• Language:English Provider:L-Serinamide hydrochloride
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS

L-Serinamide hydrochloride Usage And Synthesis

Chemical Properties

white to off-white crystals or powder

Uses

L-Serinamide Hydrochloride is used in the green synthesis of bioactive Oligopeptides.

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

General procedure for the synthesis of (S)-2-amino-3-hydroxypropionamide hydrochloride from L-serine methyl ester hydrochloride: 3.5 g (0.0225 mol) of L-serine methyl ester hydrochloride was dissolved in 100 mL of ammonia and the reaction was stirred for 48 hours at room temperature. Upon completion of the reaction, the ammonia was removed by distillation under reduced pressure, and a small amount of dilute hydrochloric acid was added to the residue to dissolve it, followed by freeze-drying of the solution to give 2.8 g of a light yellow solid product, L-serine hydrochloride, in 87.5% yield.

References

[1] Patent: CN103804341, 2018, B. Location in patent: Paragraph 0049; 0051; 0052

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