2-Bromo-5-fluoropyridine Chemical Properties

Melting point:

30-31 °C (lit.)

Boiling point:

80-83 °C/44 mmHg (lit.)

Density 

1.707±0.06 g/cm3(Predicted)

refractive index 

1.5396

Flash point:

167 °F

storage temp. 

Inert atmosphere,Room Temperature

form 

Liquid

pka

-1.63±0.10(Predicted)

color 

Colorless to slightly yellow

BRN 

1561456

CAS DataBase Reference

41404-58-4(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi,Xn,F

Risk Statements 

36/37/38-20/21/22-10

Safety Statements 

26-36-16

RIDADR 

2811

WGK Germany 

3

Hazard Note 

Irritant

HazardClass 

6.1

PackingGroup 

III

HS Code 

29333990

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

2-Bromo-5-fluoropyridine Usage And Synthesis

Chemical Properties

Light yellow Cryst

Uses

2-Bromo-5-fluoropyridine can be used in the synthesis of the following:

• 5-fluoro-2-phenylpyridine via Suzuki coupling reaction with phenylboronic acid
• 5-fluoro-2-(p-tolyl)pyridine via Suzuki coupling reaction with p-tolylboronic acid

It can undergo palladium-catalyzed homo-coupling reaction to give the corresponding biaryl. It can also be employed in a palladium-catayzed α-arylation of esters leading to 4-pyridylcarboxypiperidines.

Uses

2-Bromo-5-fluoropyridine is used in the synthesis of mGluR5 antagonist for the treatment of neuropathic pain.

2-Bromo-5-fluoropyridine(41404-58-4)Related Product Information

• 1-Hexadecylpyridinium bromide
• Chromium picolinate
• Sulfasalazine
• 2-Bromo-5-chloropyridine
• 2-Bromopyridine
• Flupirtine
• 2-Fluoropyridine
• 2,6-Lutidine
• Ethyl bromodifluoroacetate
• 2-Chloro-3-cyanopyridine
• 2-Bromo-5-fluoropyrimidine
• 2-BROMO-5-METHOXYPYRIDINE
• 2-Bromo-5-methylpyridine
• 2-Bromo-6-(trifluoromethyl)pyridine
• 2-Bromo-6-methylpyridine
• 2-BROMO-5-IODOBENZYL ALCOHOL
• 2-Bromo-5-nitropyridine
• 2-Bromo-5-(trifluoromethyl)pyridine