5,6-DIMETHYL-2-THIOURACIL Chemical Properties

Melting point:

284-288 °C(lit.)

Density 

1.2069 (rough estimate)

refractive index 

1.6490 (estimate)

storage temp. 

-20°C Freezer

solubility 

DMSO (Slightly), Methanol (Slightly, Heated)

form 

solid

pka

7.88±0.25(Predicted)

color 

White to Pale Yellow

Water Solubility 

1.373g/L(25 ºC)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

RTECS 

YQ9887000

HazardClass 

IRRITANT

HS Code 

2933599590

MSDS

• Language:English Provider:SigmaAldrich

5,6-DIMETHYL-2-THIOURACIL Usage And Synthesis

Description

5,6-dimethyl-2-Thiouracil is a heterocyclic building block that has been used in the synthesis of anti-HIV-1 pyrimidinones. It has also been used as an internal standard for the quantification of thyreostats, including 2-thiouracil, in bovine plasma.

Uses

5,6-Dimethylthiouracil is a heterocyclic building block.

References

[1] NAVROTSKII M B. Synthesis and Anti-HIV-1 Activity of New 2-[(2-Phthalimidoethyl)thio]-4(3H)-pyrimidinone Derivatives[J]. Pharmaceutical Chemistry Journal, 2005, 29 1: 466-467. DOI: 10.1007/s11094-006-0002-1
[2] SCHMIDT K S. In-house validation and factorial effect analysis of a liquid chromatography–tandem mass spectrometry method for the determination of thyreostats in bovine blood plasma[J]. Analytical and Bioanalytical Chemistry, 2013, 406 3: 735-743. DOI: 10.1007/s00216-013-7517-6

5,6-DIMETHYL-2-THIOURACIL(28456-54-4)Related Product Information

• 5,6-DIMETHYL-2-THIOURACIL
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