2-Hydrazinopyrazine Chemical Properties

Melting point:

109-113℃

Boiling point:

246.3±23.0 °C(Predicted)

Density 

1.39±0.1 g/cm3(Predicted)

storage temp. 

Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

pka

5.10±0.20(Predicted)

form 

Solid

color 

Yellow

Water Solubility 

Slightly soluble in water.

Safety Information

Hazard Codes 

Xn

Risk Statements 

22-41-36/37/38

Safety Statements 

26-39-36/37/39

HS Code 

29339900

2-Hydrazinopyrazine Usage And Synthesis

Chemical Properties

Pale yellow solid

Uses

Triazolo[4,3-a]pyrazine 7-oxide, 3-β-D-ribofuranosyl-1,2,4-triazolo[4,3-a]pyrazine, monohydrazones of pyridine, pyrazine, phenylglyoxal were synthesised from 2-Hydrazinopyrazine.

Application

2-Hydrazinopyrazine is used as a reagent in the synthesis of Sitagliptin (S491000, H3PO4) and its analogs. Sitagliptin is a trizolopyrazine dipeptidyl peptidase IV inhibitor that has recently been approved for the therapy of type II diabetes.

2-Hydrazinopyrazine(54608-52-5)Related Product Information

• Methyl 3-Oxo-4-(2,4,5-trifluorophenyl)butanoate
• Sitagliptin
• Sitagliptin S-IsoMer
• 3-(tert-butoxycarbonyl aMino)-4-(2,4,5-trifluoro phenyl)butanoic acid
• 1-(2,4,5-trifluorophenyl)propan-2-one
• (S)-1-(2,4,5-trifluorophenyl)propan-2-amine hydrochloride
• Methyl 3-aMino-4-(2,4,5-trifluorophenyl)butanoate
• tert-butyl 4-oxo-4-(3-(trifluoroMethyl)-5,6-dihydro-[1,2,4]triazolo [4,3-a]pyrazin-7(8H)-yl)-1-(2,4,5-trifluorophenyl) butan-2-ylcarbaMate
• (S)-methyl 3-amino-4-(2,4,5-trifluoro phenyl) butanoate
• 1-(2,4,5-trifluorophenyl)propan-2-amine hydrochloride
• (S)-Sitagliptin Phosphate
• 3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid
• 5-1-hydroxy-2-(2,4,5-trifluorophenyl)ethylidene-2,2-dimethyl-1,3-dioxane-4,6-dione
• Benzenebutanoicacid,b-aMino-2,4,5-trifluoro-,Methylester,(bR)-
• (R)-Methyl 3-aMino-4-(2,4,5-trifluorophenyl)butanoate hydrochloride
• (R)-Methyl 3-aMino-4-(2,4,5-trifluorophenyl) butanoate .(R)-2-hydroxy-2-phenylacetate
• 1-(2,4,5-trifluorophenyl)propan-2-amine
• (R)-1-(2,4,5-trifluorophenyl)propan-2-amine