3-Quinuclidinol
3-Quinuclidinol Basic information
- Product Name:
- 3-Quinuclidinol
- Synonyms:
-
- 3-Hydroxyxinyclidine
- dl-3-Quinuclidinol
- NSC 93905
- 1-Azabicyclo[2.2.2]octan-3-ol, 3-Hydroxyquinuclidine
- QUINICLIDINE-3-OL
- 3-Quinuclidinol,99%
- 2-Amino-N-ethylbenze
- Quinuclidin-3-ol, 1-Azabicyclo[2.2.2]octan-3-ol
- CAS:
- 1619-34-7
- MF:
- C7H13NO
- MW:
- 127.18
- EINECS:
- 216-578-4
- Product Categories:
-
- Heterocycles
- Intermediates & Fine Chemicals
- Pharmaceutical material and intermeidates
- Quinuclidine derivatives
- Pharmaceuticals
- Mol File:
- 1619-34-7.mol
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3-Quinuclidinol Chemical Properties
- Melting point:
- 220-223 °C(lit.)
- Boiling point:
- 235.98°C (rough estimate)
- Density
- 1.0083 (rough estimate)
- refractive index
- 1.4790 (estimate)
- storage temp.
- 2-8°C
- solubility
- Aqueous Acidic (Slightly), Chloroform (Sparingly), Methanol (Slightly)
- form
- Crystalline Powder
- pka
- 14.75±0.20(Predicted)
- color
- White to beige
- Water Solubility
- soluble
- Sensitive
- Air Sensitive
- Merck
- 14,8082
- BRN
- 104327
- LogP
- 0.17
- CAS DataBase Reference
- 1619-34-7(CAS DataBase Reference)
- NIST Chemistry Reference
- 3-Quinuclidinol(1619-34-7)
- EPA Substance Registry System
- 1-Azabicyclo[2.2.2]octan-3-ol (1619-34-7)
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Safety Information
- Hazard Codes
- C,F
- Risk Statements
- 34-11
- Safety Statements
- 26-36/37/39-45-16
- RIDADR
- UN 3263 8/PG 2
- WGK Germany
- 3
- RTECS
- VD6191700
- F
- 34
- Hazard Note
- Corrosive
- TSCA
- Yes
- HazardClass
- 8
- PackingGroup
- III
- HS Code
- 29333920
- Hazardous Substances Data
- 1619-34-7(Hazardous Substances Data)
MSDS
- Language:English Provider:3-Quinuclidinol
- Language:English Provider:SigmaAldrich
- Language:English Provider:ALFA
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3-Quinuclidinol Usage And Synthesis
Chemical Properties
Crystalline Solid
Uses
Hypotensive. Synthon for preparation of cholinergic receptor ligands and anesthetics
Uses
3-Quinuclidinol acts as a chiral building block for various antimuscarinic agents and other active pharmaceutical ingredients. It serves as a catalyst for condensation of methyl vinyl ketone with aldehydes. It is also used as a reagent for cleavage of beta-keto and vinylogous beta-keto esters. Further, it plays an important role as a synthon in the preparation of cholinergic receptor ligands and anesthetics. In addition to this, it is used in chemoselective alfa-iodination of acrylic esters through Morita-Baylis-Hillman reaction.
Definition
ChEBI: Quinuclidine in which a hydrogen atom at position 3 is substituted by a hydroxy group.
Hazard
Mutation.
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3-Quinuclidinol(1619-34-7)Related Product Information
- Cyproconazol
- QUINUCLIDINE
- Quinine sulfate dihydrate
- (R )-(-)-3-hydroxyquinuclidine (R)-()-3-Quinuclidinol,(R)-3-QUINUCLIDINOL,(R)-(-)-3-Quinuclidinol, 99+%,(R)-(-)-3-QUINUCLIDINOL
- (S)-3-Quinuclidinol. Hydrochloride,(S)-(+)-3-QUINUCLIDINOL
- Quinine dihydrochloride
- 2,2,4-Trimethylpentane
- 3-Quinuclidinone hydrochloride
- Solifenacin Related Compound 18
- 1-Phenyl-3,4-dihydroisoquinoline
- Solifenacin N-Oxide
- Solifenacin Impurity 1 HCl
- Solifenacin Related CoMpound 4 Succinate
- Solifenacin Related Compound 3 Succinate
- Solifenacin Related Compound 19
- Solifenacin Impurity 2
- Solifenacin Related Compound 25
- Solifenacin Related Compound 29
- Quinuclidinol