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3-Quinuclidinol

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3-Quinuclidinol Basic information

Product Name:
3-Quinuclidinol
Synonyms:
  • 3-Hydroxyxinyclidine
  • dl-3-Quinuclidinol
  • NSC 93905
  • 1-Azabicyclo[2.2.2]octan-3-ol, 3-Hydroxyquinuclidine
  • QUINICLIDINE-3-OL
  • 3-Quinuclidinol,99%
  • 2-Amino-N-ethylbenze
  • Quinuclidin-3-ol, 1-Azabicyclo[2.2.2]octan-3-ol
CAS:
1619-34-7
MF:
C7H13NO
MW:
127.18
EINECS:
216-578-4
Product Categories:
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceutical material and intermeidates
  • Quinuclidine derivatives
  • Pharmaceuticals
Mol File:
1619-34-7.mol
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3-Quinuclidinol Chemical Properties

Melting point:
220-223 °C(lit.)
Boiling point:
235.98°C (rough estimate)
Density 
1.0083 (rough estimate)
refractive index 
1.4790 (estimate)
storage temp. 
2-8°C
solubility 
Aqueous Acidic (Slightly), Chloroform (Sparingly), Methanol (Slightly)
form 
Crystalline Powder
pka
14.75±0.20(Predicted)
color 
White to beige
Water Solubility 
soluble
Sensitive 
Air Sensitive
Merck 
14,8082
BRN 
104327
LogP
0.17
CAS DataBase Reference
1619-34-7(CAS DataBase Reference)
NIST Chemistry Reference
3-Quinuclidinol(1619-34-7)
EPA Substance Registry System
1-Azabicyclo[2.2.2]octan-3-ol (1619-34-7)
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Safety Information

Hazard Codes 
C,F
Risk Statements 
34-11
Safety Statements 
26-36/37/39-45-16
RIDADR 
UN 3263 8/PG 2
WGK Germany 
3
RTECS 
VD6191700
34
Hazard Note 
Corrosive
TSCA 
Yes
HazardClass 
8
PackingGroup 
III
HS Code 
29333920
Hazardous Substances Data
1619-34-7(Hazardous Substances Data)

MSDS

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3-Quinuclidinol Usage And Synthesis

Chemical Properties

Crystalline Solid

Uses

Hypotensive. Synthon for preparation of cholinergic receptor ligands and anesthetics

Uses

3-Quinuclidinol acts as a chiral building block for various antimuscarinic agents and other active pharmaceutical ingredients. It serves as a catalyst for condensation of methyl vinyl ketone with aldehydes. It is also used as a reagent for cleavage of beta-keto and vinylogous beta-keto esters. Further, it plays an important role as a synthon in the preparation of cholinergic receptor ligands and anesthetics. In addition to this, it is used in chemoselective alfa-iodination of acrylic esters through Morita-Baylis-Hillman reaction.

Definition

ChEBI: Quinuclidine in which a hydrogen atom at position 3 is substituted by a hydroxy group.

Hazard

Mutation.

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