TETRAHYDROFURAN-D8 Chemical Properties

Melting point:

−106 °C(lit.)

Melting point:

-108,5°C

Boiling point:

66°C

Boiling point:

65-66 °C(lit.)

Density 

0.985 g/mL at 25 °C(lit.)

Density 

d = 0,99

refractive index 

n20/D 1.403(lit.)

Flash point:

1 °F

storage temp. 

2-8°C

solubility 

Chloroform (Slightly), Methanol (Slightly)

form 

Liquid

color 

Colorless

Specific Gravity

0.99

Water Solubility 

Soluble in water.

BRN 

111854

Stability:

Stable. Incompatible with strong oxidizing agents, strong reducing agents, strong bases, oxygen. May generate peroxides in storage if in contact with air. Highly flammable. Store under nitrogen. Hazardous polymerisation may occur.

InChI

1S/C4H8O/c1-2-4-5-3-1/h1-4H2/i1D2,2D2,3D2,4D2

InChIKey

WYURNTSHIVDZCO-SVYQBANQSA-N

SMILES

[2H]C1([2H])OC([2H])([2H])C([2H])([2H])C1([2H])[2H]

CAS DataBase Reference

1693-74-9(CAS DataBase Reference)

EPA Substance Registry System

Furan-2,3,4,5-d4, tetrahydro-d4- (1693-74-9)

Safety Information

Hazard Codes 

F,Xn,Xi

Risk Statements 

11-19-36/37-40

Safety Statements 

16-29-33-46-37-36-13-36/37

RIDADR 

UN 2056 3/PG 2

WGK Germany 

3

RTECS 

LU5950000

Autoignition Temperature

215 °C

HS Code 

2845 90 10

HazardClass 

3

PackingGroup 

II

Storage Class

3 - Flammable liquids

Hazard Classifications

Acute Tox. 4 Oral
Carc. 2
Eye Irrit. 2
Flam. Liq. 2
STOT SE 3

Toxicity

LD50 orally in Rabbit: 1650 mg/kg

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

TETRAHYDROFURAN-D8 Usage And Synthesis

Chemical Properties

colourless liquid with an ether-like odour

Uses

Tetrahydrofuran-d_8 is a deuterated THF that is used in various synthesis reactions and also used as a precursor for various polymers.

Definition

ChEBI: Oxolane-d8 is a deuterated compound, a cyclic ether, a member of oxolanes, a saturated organic heteromonocyclic parent and a volatile organic compound.

General Description

Tetrahydrofuran-d₈ may be used as a solvent in the synthesis of deuteriotris[bis(trimethylsilyl)amido]thorium and deuteriotris[bis(trimethylsiiyl)amido]uranium.

Synthesis

Tetrahydrofuran-d8 was prepared from the exchange of tetrahydrofuran with heavy water catalyzed by a transition metal: a CD3OD mixture of tetrahydrofuran (0.22 mmol) and pyrene-imidazolylidene-iridium(III) complex (2 mol% based on the metal) was heated in a Schlenk tube equipped with a Teflon cap at 100??C. AgOTf (8.8 ?? 10-3 mmol) was added to the solution. After 12 h, a 50-??L aliquot was withdrawn from the reaction vessel. An aliquot was added to an NMR tube containing 0.6 mL of CDCl3. Highly substituted tetrahydrofuran-d8 was obtained using a standard capillary consisting of a solution of ferrocene in CDCl3 (0.025 mg ??L-1) and the deuteration level was monitored by 1H NMR.

TETRAHYDROFURAN-D8(1693-74-9)Related Product Information

• ETHANOL-1,1-D2
• TETRAHYDROFURAN-D8
• 4-amino-1-[3,3-difluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-1h-pyrimidin-2-one hydrochloride
• 5-ISOPROPENYL-2-METHYL-2-VINYL TETRAHYDROFURAN
• PROPANOL-2,2-D2
• PROPANE-2-D1
• 1-BUTANOL-1,1,2,2-D4
• METHYL-D1 ALCOHOL
• N-BUTANE-1,4-D2
• PROPYL-1,1-D2 ALCOHOL
• ETHYL-1-D1 ALCOHOL
• PROPANE-2,2-D2
• N-BUTYL-1,1-D2 ALCOHOL
• N-BUTANE-2,2,3,3-D4
• ETHANOL-2-D1
• ETHANE-1,1,2,2-D4
• PROPANOL-1,1,2,2-D4
• METHANOL (D2)