N-(4-BROMOPHENYL)MORPHOLINE
N-(4-BROMOPHENYL)MORPHOLINE Basic information
- Product Name:
- N-(4-BROMOPHENYL)MORPHOLINE
- Synonyms:
-
- N-(4-BROMOPHENYL)MORPHOLINE
- 4-(4'-BROMOPHENYL)MORPHOLINE
- 1-Bromo-4-morpholinobenzene
- 4-(4-Bromophenyl)morpholine 97%
- Morpholine,4-(4-bromophenyl)-
- CAS:
- 30483-75-1
- MF:
- C10H12BrNO
- MW:
- 242.11
- Product Categories:
-
- Building Blocks
- Chemical Synthesis
- pharmacetical
- Halogenated Heterocycles
- Heterocyclic Building Blocks
- Morpholines/Thiomorpholines
- Miscellaneous
- Mol File:
- 30483-75-1.mol
N-(4-BROMOPHENYL)MORPHOLINE Chemical Properties
- Melting point:
- 114-118 °C (lit.)
- Boiling point:
- 341.2±37.0 °C(Predicted)
- Density
- 1.433±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- form
- powder to crystal
- pka
- 4.33±0.40(Predicted)
- color
- White to Light yellow to Light orange
MSDS
- Language:English Provider:SigmaAldrich
N-(4-BROMOPHENYL)MORPHOLINE Usage And Synthesis
Uses
N-(4-BROMOPHENYL)MORPHOLINE is used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process.
Synthesis
In an open flask, 10 mL of 1.5 M NaBr in pH 6.2 phosphate buffer (0.23 M in PO4) or pH 4.2 phosphate buffer (5% NaH2PO4) was added to a solution of 1 mmol of substrate dissolved in 9.75 mL of distilled 1,4- dioxane. To this mixture was added a freshly made solution of diphenyl ditelluride (1e, 0.25 mL of a 10 mM stock in 1,4-dioxane, 2.5 μmol, 0.25 mol % relative to substrate) followed by the addition of 8.8 M H2O2 according to Table 3. The reaction mixture was stirred at room temperature for the appropriate amount of time and was then diluted with 10 mL of water. The resulting solution was extracted with EtOAc (3 × 10 mL), and the combined organic extracts were washed with 0.5 M NaHSO3 (5 mL) and brine (10 mL), dried over MgSO4, and concentrated. Yields reported below are the mean of duplicate runs. N-(4-Bromophenyl)morpholine (21):28 product isolated as a tan solid (224 ± 1 mg, 93% yield). Mp 111-113 °C (lit.28 mp 111-112 °C).
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N-(4-BROMOPHENYL)MORPHOLINE(30483-75-1)Related Product Information
- Moroxydine
- 2-Bromotoluene
- (1-Bromoethyl)benzene
- Diphenhydramine
- 4-(3-BROMOPHENYL)MORPHOLINE
- N-(4-BROMOPHENYL)MORPHOLINE
- 5-BROMO-2-MORPHOLIN-4-YLANILINE
- 5-BROMO-2-(N-MORPHOLINO)-BENZALDEHYDE
- 1-(3-Bromo-4-morpholin-4-ylphenyl)ethan-1-one, 4-(4-Acetyl-2-bromophenyl)morpholine
- N-(2-bromophenyl)morpholine-4-sulfonamide
- N-(2-amino-4-bromophenyl)morpholine-4-sulfonamide
- N-(4-bromophenyl)morpholine-4-sulfonamide
- N-(3-bromophenyl)morpholine-4-sulfonamide
- RARECHEM AN KC 2209
- RARECHEM AN KA 2213
- RARECHEM AN KB 2218
- RARECHEM AN KD 2228
- 7-BROMO-4-MORPHOLIN-4-YL-5-NITRO-2,1,3-BENZOTHIADIAZOLE