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N-(4-BROMOPHENYL)MORPHOLINE

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N-(4-BROMOPHENYL)MORPHOLINE Basic information

Product Name:
N-(4-BROMOPHENYL)MORPHOLINE
Synonyms:
  • N-(4-BROMOPHENYL)MORPHOLINE
  • 4-(4'-BROMOPHENYL)MORPHOLINE
  • 1-Bromo-4-morpholinobenzene
  • 4-(4-Bromophenyl)morpholine 97%
  • Morpholine,4-(4-bromophenyl)-
CAS:
30483-75-1
MF:
C10H12BrNO
MW:
242.11
Product Categories:
  • Building Blocks
  • Chemical Synthesis
  • pharmacetical
  • Halogenated Heterocycles
  • Heterocyclic Building Blocks
  • Morpholines/Thiomorpholines
  • Miscellaneous
Mol File:
30483-75-1.mol
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N-(4-BROMOPHENYL)MORPHOLINE Chemical Properties

Melting point:
114-118 °C (lit.)
Boiling point:
341.2±37.0 °C(Predicted)
Density 
1.433±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
form 
powder to crystal
pka
4.33±0.40(Predicted)
color 
White to Light yellow to Light orange
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Safety Information

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
HS Code 
2934999090

MSDS

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N-(4-BROMOPHENYL)MORPHOLINE Usage And Synthesis

Uses

N-(4-BROMOPHENYL)MORPHOLINE is used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process.

Synthesis


In an open flask, 10 mL of 1.5 M NaBr in pH 6.2 phosphate buffer (0.23 M in PO4) or pH 4.2 phosphate buffer (5% NaH2PO4) was added to a solution of 1 mmol of substrate dissolved in 9.75 mL of distilled 1,4- dioxane. To this mixture was added a freshly made solution of diphenyl ditelluride (1e, 0.25 mL of a 10 mM stock in 1,4-dioxane, 2.5 μmol, 0.25 mol % relative to substrate) followed by the addition of 8.8 M H2O2 according to Table 3. The reaction mixture was stirred at room temperature for the appropriate amount of time and was then diluted with 10 mL of water. The resulting solution was extracted with EtOAc (3 × 10 mL), and the combined organic extracts were washed with 0.5 M NaHSO3 (5 mL) and brine (10 mL), dried over MgSO4, and concentrated. Yields reported below are the mean of duplicate runs. N-(4-Bromophenyl)morpholine (21):28 product isolated as a tan solid (224 ± 1 mg, 93% yield). Mp 111-113 °C (lit.28 mp 111-112 °C).

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