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L-Arginine hydrochloride

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L-Arginine hydrochloride Basic information

Product Name:
L-Arginine hydrochloride
Synonyms:
  • argininemonohydrochloride
  • argivene
  • minophagena
  • monohydrochloride,l-arginin
  • r-gene
  • 2-amino-5-guanidinovaleric acid monohydrochloride
  • L(+)-Arginine hydrochloride
  • ARGININE HYDROCHLORID
CAS:
1119-34-2
MF:
C6H15ClN4O2
MW:
210.66
EINECS:
214-275-1
Product Categories:
  • Nutritional Supplements
  • L-Amino Acids
  • alpha-Amino Acids
  • Amino Acids
  • Biochemistry
  • for Resolution of Acids
  • chiral
  • Amino Acid Derivatives
  • Amino Acids 13C, 2H, 15N
  • Optical Resolution
  • Synthetic Organic Chemistry
  • Amino Acids
  • Amino Acids, Peptides and Proteins
  • Life Sciences Standards
  • Amino Acids & Derivatives
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • PRILOSEC
  • amino
  • VX:15689727968
Mol File:
1119-34-2.mol
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L-Arginine hydrochloride Chemical Properties

Melting point:
226-230 °C(lit.)
alpha 
22 º (c=8,6N HCl)
Density 
1.42
vapor pressure 
<1 Pa (20 °C)
FEMA 
3819 | L-ARGININE
storage temp. 
2-8°C
solubility 
H2O: 100 mg/mL
form 
powder
color 
white
Odor
odorless
PH
5.5-7.0 (25℃, 1M in H2O)
PH Range
5.5 - 7
optical activity
[α]20/D +22.0±0.5°, c = 5% in 5 M HCl
Water Solubility 
Soluble in water. Slightly soluble in hot alcohol.
λmax
λ: 260 nm Amax: ≤0.2
λ: 280 nm Amax: ≤0.1
Sensitive 
Hygroscopic
Merck 
14,780
BRN 
3631658
Stability:
Stable. Incompatible with strong oxidizing agents.
CAS DataBase Reference
1119-34-2(CAS DataBase Reference)
EPA Substance Registry System
L-Arginine, monohydrochloride (1119-34-2)
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Safety Information

Hazard Codes 
Xi,Xn
Risk Statements 
37-36/38-36/37/38-20/21/22
Safety Statements 
37/39-26-24/25-36
WGK Germany 
2
RTECS 
CF1995500
3-10
TSCA 
Yes
HS Code 
29252000
Toxicity
LD50 orally in Rabbit: 12000 mg/kg

MSDS

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L-Arginine hydrochloride Usage And Synthesis

Chemical Properties

White crystalline powder

Uses

gastric acid depressant

Uses

An essential amino acid for human development. Precursor for nitric oxide. Ammonia detoxicant (hepatic failure); diagnostic aid (pituitary function).

Uses

L-Arginine monohydrochloride is used in the treatment of heart and circulatory diseases. It is a precursor of nitric oxide synthesis that induces vasodilation in vivo, there by relaxing blood vessels. It is also used in the treatment of angina and other cardiovascular problems. It is an important intermediate in the urea cycle and involved in the detoxification of nitrogenous wastes. It is commonly used in cell culture media and drug development.

brand name

R-Gene 10 (Pharmacia & Upjohn).

General Description

This certified reference material (CRM) is produced and certified in accordance with ISO/IEC 17025 and ISO 17034. This CRM is traceable to primary material from an NMI, e.g. NIST or NMIJ.
Certified content by quantitative NMR incl. uncertainty and expiry date are given on the certificate.
Download your certificate at: http://www.sigma-aldrich.com.

Biochem/physiol Actions

L-Arginine is considered as a semi essential amino acid. In most mammals including humans, L-Arginine synthesis occurs through intestinal-renal axis, from glutamine, glutamate and proline. Abnormal levels of L-Arginine is associated with the development of kidney and cardiovascular disease. L-arginine is found to decrease fat mass and visceral adiposity.

Safety Profile

Moderately toxic by intraperitoneal route. Mildly toxic by ingestion. An experimental teratogen. When heated to decomposition it emits very toxic fumes of NOx and HCl.

Purification Methods

A likely impurity is ornithine. Crystallise the salt from H2O at pH 5-7, by adding EtOH to 80% (v/v). [Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 p 1841 1961, Beilstein 4 IV 2649.]

L-Arginine hydrochloride Preparation Products And Raw materials

Raw materials

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