L-Arginine hydrochloride Chemical Properties

Melting point:

226-230 °C(lit.)

alpha 

22 º (c=8,6N HCl)

Boiling point:

235℃[at 101 325 Pa]

Density 

1.42

vapor pressure 

<1 Pa (20 °C)

FEMA 

3819 | L-ARGININE

storage temp. 

2-8°C

solubility 

H₂O: 100 mg/mL

form 

powder

pka

1[at 20 ℃]

color 

white

PH

5.5-7.0 (25℃, 1M in H2O)

Odor

odorless

PH Range

5.5 - 7

optical activity

[α]20/D +22.0±0.5°, c = 5% in 5 M HCl

Water Solubility 

Soluble in water. Slightly soluble in hot alcohol.

Sensitive 

Hygroscopic

λmax

λ: 260 nm Amax: ≤0.2
λ: 280 nm Amax: ≤0.1

Merck 

14,780

BRN 

3631658

Stability:

Stable. Incompatible with strong oxidizing agents.

LogP

-8.5--3.24 at 25℃

CAS DataBase Reference

1119-34-2(CAS DataBase Reference)

EPA Substance Registry System

L-Arginine, monohydrochloride (1119-34-2)

Safety Information

Hazard Codes 

Xi,Xn

Risk Statements 

37-36/38-36/37/38-20/21/22

Safety Statements 

37/39-26-24/25-36

WGK Germany 

2

RTECS 

CF1995500

F 

3-10

TSCA 

Yes

HS Code 

29252000

Toxicity

LD50 orally in Rabbit: 12000 mg/kg

MSDS

• Language:English Provider:2-Amino-5-guanidinovaleric acid monohydrochloride
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

L-Arginine hydrochloride Usage And Synthesis

Description

L-Arginine hydrochloride is a salt form of L-Arginine, where hydrochloric acid is added to enhance stability and solubility. Arginine hydrochloride is a L-alpha-amino acid. An essential amino acid that is physiologically active in the L-form. L-Arginine might be effective at lowering blood pressure, reducing the symptoms of angina and PAD , and treating erectile dysfunction due to a physical cause.

Chemical Properties

White crystalline powder

Uses

gastric acid depressant

Uses

L-Arginine monohydrochloride is used in the treatment of heart and circulatory diseases. It is a precursor of nitric oxide synthesis that induces vasodilation in vivo, there by relaxing blood vessels. It is also used in the treatment of angina and other cardiovascular problems. It is an important intermediate in the urea cycle and involved in the detoxification of nitrogenous wastes. It is commonly used in cell culture media and drug development.

Uses

An essential amino acid for human development. Precursor for nitric oxide. Ammonia detoxicant (hepatic failure); diagnostic aid (pituitary function).

Definition

ChEBI: Arginine hydrochloride is a L-alpha-amino acid.

brand name

R-Gene 10 (Pharmacia & Upjohn).

Biochem/physiol Actions

L-Arginine is considered as a semi essential amino acid. In most mammals including humans, L-Arginine synthesis occurs through intestinal-renal axis, from glutamine, glutamate and proline. Abnormal levels of L-Arginine is associated with the development of kidney and cardiovascular disease. L-arginine is found to decrease fat mass and visceral adiposity.

Side effects

L-arginine has some potential side effects to consider when taking it as a supplement. Some of the more common and benign side effects can include: nausea, diarrhea, bloating, and abdominal pain. However, L-arginine may result in some serious complications.

Safety Profile

Moderately toxic by intraperitoneal route. Mildly toxic by ingestion. An experimental teratogen. When heated to decomposition it emits very toxic fumes of NOx and HCl.

Purification Methods

A likely impurity is ornithine. Crystallise the salt from H2O at pH 5-7, by adding EtOH to 80% (v/v). [Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 p 1841 1961, Beilstein 4 IV 2649.]

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