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L-Arginine hydrochloride

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L-Arginine hydrochloride Basic information

Product Name:
L-Arginine hydrochloride
Synonyms:
  • argininemonohydrochloride
  • argivene
  • minophagena
  • monohydrochloride,l-arginin
  • r-gene
  • 2-amino-5-guanidinovaleric acid monohydrochloride
  • L(+)-Arginine hydrochloride
  • ARGININE HYDROCHLORID
CAS:
1119-34-2
MF:
C6H15ClN4O2
MW:
210.66
EINECS:
214-275-1
Product Categories:
  • Nutritional Supplements
  • L-Amino Acids
  • alpha-Amino Acids
  • Amino Acids
  • Biochemistry
  • for Resolution of Acids
  • chiral
  • Amino Acid Derivatives
  • Amino Acids 13C, 2H, 15N
  • Optical Resolution
  • Synthetic Organic Chemistry
  • Amino Acids
  • Amino Acids, Peptides and Proteins
  • Life Sciences Standards
  • Amino Acids & Derivatives
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • PRILOSEC
  • amino
  • 1119-34-2
Mol File:
1119-34-2.mol
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L-Arginine hydrochloride Chemical Properties

Melting point:
226-230 °C(lit.)
alpha 
22 º (c=8,6N HCl)
Boiling point:
235℃[at 101 325 Pa]
Density 
1.42
vapor pressure 
<1 Pa (20 °C)
FEMA 
3819 | L-ARGININE
storage temp. 
2-8°C
solubility 
H2O: 100 mg/mL
form 
powder
pka
1[at 20 ℃]
color 
white
Odor
odorless
PH Range
5.5 - 7
PH
5.5-7.0 (25℃, 1M in H2O)
optical activity
[α]20/D +22.0±0.5°, c = 5% in 5 M HCl
Water Solubility 
Soluble in water. Slightly soluble in hot alcohol.
Sensitive 
Hygroscopic
λmax
λ: 260 nm Amax: ≤0.2
λ: 280 nm Amax: ≤0.1
Merck 
14,780
BRN 
3631658
Stability:
Stable. Incompatible with strong oxidizing agents.
LogP
-8.5--3.24 at 25℃
CAS DataBase Reference
1119-34-2(CAS DataBase Reference)
EPA Substance Registry System
L-Arginine, monohydrochloride (1119-34-2)
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Safety Information

Hazard Codes 
Xi,Xn
Risk Statements 
37-36/38-36/37/38-20/21/22
Safety Statements 
37/39-26-24/25-36
WGK Germany 
2
RTECS 
CF1995500
3-10
TSCA 
Yes
HS Code 
29252000
Toxicity
LD50 orally in Rabbit: 12000 mg/kg

MSDS

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L-Arginine hydrochloride Usage And Synthesis

Description

L-Arginine hydrochloride is a salt form of L-Arginine, where hydrochloric acid is added to enhance stability and solubility. Arginine hydrochloride is a L-alpha-amino acid. An essential amino acid that is physiologically active in the L-form. L-Arginine might be effective at lowering blood pressure, reducing the symptoms of angina and PAD , and treating erectile dysfunction due to a physical cause.

Chemical Properties

White crystalline powder

Uses

gastric acid depressant

Uses

L-Arginine monohydrochloride is used in the treatment of heart and circulatory diseases. It is a precursor of nitric oxide synthesis that induces vasodilation in vivo, there by relaxing blood vessels. It is also used in the treatment of angina and other cardiovascular problems. It is an important intermediate in the urea cycle and involved in the detoxification of nitrogenous wastes. It is commonly used in cell culture media and drug development.

Uses

An essential amino acid for human development. Precursor for nitric oxide. Ammonia detoxicant (hepatic failure); diagnostic aid (pituitary function).

Definition

ChEBI: Arginine hydrochloride is a L-alpha-amino acid.

brand name

R-Gene 10 (Pharmacia & Upjohn).

Biochem/physiol Actions

L-Arginine is considered as a semi essential amino acid. In most mammals including humans, L-Arginine synthesis occurs through intestinal-renal axis, from glutamine, glutamate and proline. Abnormal levels of L-Arginine is associated with the development of kidney and cardiovascular disease. L-arginine is found to decrease fat mass and visceral adiposity.

Side effects

L-arginine has some potential side effects to consider when taking it as a supplement. Some of the more common and benign side effects can include: nausea, diarrhea, bloating, and abdominal pain. However, L-arginine may result in some serious complications.

Safety Profile

Moderately toxic by intraperitoneal route. Mildly toxic by ingestion. An experimental teratogen. When heated to decomposition it emits very toxic fumes of NOx and HCl.

Purification Methods

A likely impurity is ornithine. Crystallise the salt from H2O at pH 5-7, by adding EtOH to 80% (v/v). [Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 p 1841 1961, Beilstein 4 IV 2649.]

L-Arginine hydrochloride Preparation Products And Raw materials

Raw materials

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