Pamidronate disodium salt Chemical Properties

Melting point:

300 °C

storage temp. 

2-8°C

solubility 

H₂O: 28 mg/mL

form 

solid

color 

white

Merck 

14,7003

Stability:

Hygroscopic

CAS DataBase Reference

57248-88-1(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn

Risk Statements 

22-48-41-37/38-20/21/22

Safety Statements 

22-26-36/37/39-45

RIDADR 

3077

WGK Germany 

3

RTECS 

SZ6525000

HazardClass 

IRRITANT

HS Code 

29319090

Pamidronate disodium salt Usage And Synthesis

Description

Disodium pamidronate is a calcium metabolism regulator useful in the treatment of hypercalcemia associated with malignancy. It presumably reduces the bone resorption of calcium by inhibiting the formation and attachment of osteoclasts. Other potential uses include osteoporosis and calcitonin-resistant Paget’s disease.

Chemical Properties

White Crystals

Originator

Henkel (United Kingdom)

Uses

Pamidronate disodium is a nitrogen containing bisphosphonate, used to prevent osteoporosis. It is used to prevent bone loss, and treat osteoporosis.

Uses

A farnesyl diphosphate synthase inhibitor

Uses

A bisphosphonate antiresorptive agent; bone resorption inhibitor.

Manufacturing Process

For a batch size of 5 L, 587.5 g (3.2 moles) of mannitol is dissolved in 3.5 L of water. Pamidronic acid (31.6 g, 0.133 moles) is mixed with a 1.0 L aliquot of the mannitol solution to form a slurry. The slurry is then transferred into the remainder of the mannitol solution, and stirred for at least 15 min. Aqueous 1 N sodium hydroxide (270 ml) is then added and the mixture is stirred until a clear, colorless solution results. The pH is then adjusted to 6.50.1 using either 1 M aqueous phosphoric acid or 1 N aqueous sodium hydroxide, as needed. The solution is then filtered through a 0.22 micron filter, and filled at 20°C into vials at 4.0 ml (4.172 g)/vial, under sterile conditions. The aqueous solution is frozen at -37°C and lyophilized (20 mbar, 20°-40°C) to yield 1,250 vials, each containing 30 mg of amorphous disodium pamidronate. The vials are sealed under positive nitrogen pressure. The disodium pamidronate is amorphous (noncrystalline) by X-ray diffraction and contains 0.7 wt-% water.

brand name

Aredia (Novartis).

Therapeutic Function

Bone resorption suppressant

Biochem/physiol Actions

Pamidronate disodium?has the ability to block Wnt and β-catenin signaling, which modulates the osteogenic differentiation in bone marrow mesenchymal stem cells (BMMSCs). It can also reduce bilirubin-impaired apoptosis and helps to develop dentinogenic dysfunction of stem cells from human deciduous teeth.

Veterinary Drugs and Treatments

Pamidronate may be useful in treating hypercalcemia associated with vitamin D-related toxicoses or hypercalcemia of malignancy. There is ongoing research on the use of this drug to determine if it has clinical usefulness in directly treating “micro-metastases” in osteosarcomas.

Pamidronate disodium salt(57248-88-1)Related Product Information

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