Basic information Safety Supplier Related

NALOXONAZINE DIHYDROCHLORIDE

Basic information Safety Supplier Related

NALOXONAZINE DIHYDROCHLORIDE Basic information

Product Name:
NALOXONAZINE DIHYDROCHLORIDE
Synonyms:
  • BIS-[5-ALPHA-4,5-EPOXY-3-14-DIHYDROXY-17-(2-PROPENYL)MORPHAN-6-YLIDENE]HYDRAZINE 2HCL
  • BIS-[5-ALPHA-4,5-EPOXY-3,14-DIHYDROXY-17-(2-PROPENYL)-MORPHINAN-6-YLIDENE] HYDRAZINE DIHYDROCHLORIDE
  • BIS(5-ALPHA-4,5-EPOXY-3,14-DIHYDROXY-17-[2-PROPENYL]MORPHINAN-6-YLIDENE)HYDRAZONE DIHYDROCHLORIDE
  • NALOXONAZINE 2HCL
  • NALOXONAZINE DIHYDROCHLORIDE
  • NALOXONAZINE DIHYDROCHLORIDE OPIOID ANTA GONIST
  • bis[(5α)-4,5-epoxy-3,14-dihydroxy-17-(2-propenyl)morphinan-6-ylidene]hydrazone dihydrochloride
  • naloxonazine
CAS:
82824-01-9
MF:
C38H44Cl2N4O6
MW:
723.69
Product Categories:
  • Opioid receptor and opioid-like receptor
Mol File:
82824-01-9.mol
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NALOXONAZINE DIHYDROCHLORIDE Chemical Properties

Density 
1.58±0.1 g/cm3(Predicted)
storage temp. 
−20°C
solubility 
H2O: >2 mg/mL
form 
solid
pka
8.92±0.40(Predicted)
color 
off-white to light tan
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Safety Information

WGK Germany 
3
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NALOXONAZINE DIHYDROCHLORIDE Usage And Synthesis

Uses

Naloxonazine Dihydrochloride is a selective μ1 antagonist.

Biological Activity

Potent opioid antagonist, selective for μ 1 receptors.

in vivo

Naloxonazine (0-15 mg/kg, i.p., 20 h) results that (olfactory discriminative stimulus)S+/CS+ correlated responses are significantly reduced by about 55% at a dose of 15 mg/kg, from 14.63 to 6.82. However, greater behavioral inhibition is observed in the (olfactory stimulus)S?/CS? stimulus condition, with a 66% reduction in response rate from 9.00 to 3.00 in male Wistar rats[2].

IC 50

Leishmania

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