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α-Chloralose

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α-Chloralose Basic information

Product Name:
α-Chloralose
Synonyms:
  • (r)-1,2-o-(2,2,2-trichloroethylidene)-alpha-d-glucofuranose
  • 2-o-(2,2,2-trichloroethylidene)-(r)-alpha-d-glucofuranos
  • 2-o-(2,2,2-trichloroethylidene)-(theta)-alpha-d-glucofuranos
  • alfamat
  • alpha-chloralos
  • alphakil
  • aphosal
  • chloralosane
CAS:
15879-93-3
MF:
C8H11Cl3O6
MW:
309.53
EINECS:
240-016-7
Product Categories:
  • Dextrins、Sugar & Carbohydrates
  • Biochemistry
  • Glucose
  • O-Substituted Sugars
  • Sugars
  • 15879-93-3
Mol File:
15879-93-3.mol
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α-Chloralose Chemical Properties

Melting point:
178-182 °C
alpha 
18 º (c=2, 95% C2H5OH)
Boiling point:
424.33°C (rough estimate)
Density 
1.6066 (rough estimate)
vapor pressure 
Negligible at room temperature
refractive index 
1.5320 (estimate)
solubility 
ethanol: 10 mg/mL or yellow-brown, clear to slightly hazy, colorless to faintly yellow
pka
12.89±0.60(Predicted)
form 
Solid
color 
White to Almost white
optical activity
[α]20/D +17±2°, 5 hr, c = 2% in ethanol
Water Solubility 
0.44 g/100 mL (15 ºC)
Merck 
14,2072
BRN 
85418
Stability:
Stable. Incompatible with strong oxidizing agents.
LogP
1.020
CAS DataBase Reference
15879-93-3(CAS DataBase Reference)
EPA Substance Registry System
Chloralose (15879-93-3)
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Safety Information

Hazard Codes 
Xn
Risk Statements 
20/22-20/21/22
Safety Statements 
16-24/25-28-28A-36
RIDADR 
3249
WGK Germany 
1
RTECS 
FM9450000
TSCA 
Yes
HazardClass 
6.1(b)
PackingGroup 
III
HS Code 
29400090
Toxicity
LD50 orally in mice: 400 mg/kg (Schafer)

MSDS

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α-Chloralose Usage And Synthesis

Description

Chloralose, (R)-1,2-O-(2,2,2-trichloroethylidene)- α-D-glucofuranose, is a crystalline powder which is soluble in water, fairly soluble in alcohol, diethyl ether, glacial acetic acid, sparingly soluble in chloroform, practically insoluble in petroleum ether.
Chloralose is produced by reaction of glucose with waterfree chloral under heating (21).

Chemical Properties

needle-like crystals or powder

Uses

Coating seeds to protect them from birds.

Uses

It has been employed widely as an animal anesthetic in the laboratory setting. alpha-chloralose is a true anesthetic or an immobilizing agent with sedative-hypnotic properties has important implications. Canada geese (Branta canadensis) and blue geese (Chen caerulescens) were caught with alpha-chloralose, an oral hypnotic administered on bait. Wild turkeys (Meleagris gallopavo) were captured with alpha-chloralose, an oral anesthetic.

Uses

Chloralose is used for the control of rodents, particularly mice, and as a bird repellent and a bird narcotic.

Hazard

May cause addiction, highly toxic.

Safety Profile

Poison by ingestion, subcutaneous, and intraperitoneal routes. Questionable carcinogen with experimental tumorigenic data. When heated to decomposition it emits toxic fumes of Cl-.

Metabolic pathway

Chloralose is effectively a chloral generator which, in turn, affords trichloroethanol by metabolism. This is the narcotic agent. Sleep is induced in mice before death and therefore the compound is regarded as a humane mouse killer. It is particularly effective when a quick clearout is required but there is evidence that mice can become tolerant.

Degradation

Chloralose is hydrolysed by acid and base to glucose and chloral (2, trichloroacetaldehyde).

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