α-Chloralose
α-Chloralose Basic information
- Product Name:
- α-Chloralose
- Synonyms:
-
- (r)-1,2-o-(2,2,2-trichloroethylidene)-alpha-d-glucofuranose
- 2-o-(2,2,2-trichloroethylidene)-(r)-alpha-d-glucofuranos
- 2-o-(2,2,2-trichloroethylidene)-(theta)-alpha-d-glucofuranos
- alfamat
- alpha-chloralos
- alphakil
- aphosal
- chloralosane
- CAS:
- 15879-93-3
- MF:
- C8H11Cl3O6
- MW:
- 309.53
- EINECS:
- 240-016-7
- Product Categories:
-
- Dextrins、Sugar & Carbohydrates
- Biochemistry
- Glucose
- O-Substituted Sugars
- Sugars
- 15879-93-3
- Mol File:
- 15879-93-3.mol
α-Chloralose Chemical Properties
- Melting point:
- 178-182 °C
- alpha
- 18 º (c=2, 95% C2H5OH)
- Boiling point:
- 424.33°C (rough estimate)
- Density
- 1.6066 (rough estimate)
- vapor pressure
- Negligible at room temperature
- refractive index
- 1.5320 (estimate)
- solubility
- ethanol: 10 mg/mL or yellow-brown, clear to slightly hazy, colorless to faintly yellow
- pka
- 12.89±0.60(Predicted)
- form
- Solid
- color
- White to Almost white
- optical activity
- [α]20/D +17±2°, 5 hr, c = 2% in ethanol
- Water Solubility
- 0.44 g/100 mL (15 ºC)
- Merck
- 14,2072
- BRN
- 85418
- Stability:
- Stable. Incompatible with strong oxidizing agents.
- LogP
- 1.020
- CAS DataBase Reference
- 15879-93-3(CAS DataBase Reference)
- EPA Substance Registry System
- Chloralose (15879-93-3)
Safety Information
- Hazard Codes
- Xn
- Risk Statements
- 20/22-20/21/22
- Safety Statements
- 16-24/25-28-28A-36
- RIDADR
- 3249
- WGK Germany
- 1
- RTECS
- FM9450000
- TSCA
- Yes
- HazardClass
- 6.1(b)
- PackingGroup
- III
- HS Code
- 29400090
- Toxicity
- LD50 orally in mice: 400 mg/kg (Schafer)
MSDS
- Language:English Provider:1,2-O-(2,2,2-Trichloroethylidene)-alpha-D-glucofuranose
- Language:English Provider:SigmaAldrich
- Language:English Provider:ACROS
- Language:English Provider:ALFA
α-Chloralose Usage And Synthesis
Description
Chloralose, (R)-1,2-O-(2,2,2-trichloroethylidene)-
α-D-glucofuranose, is a crystalline powder which is soluble in water,
fairly soluble in alcohol, diethyl ether, glacial acetic acid,
sparingly soluble in chloroform, practically insoluble in
petroleum ether.
Chloralose is produced by reaction of glucose with waterfree
chloral under heating (21).
Chemical Properties
needle-like crystals or powder
Uses
Coating seeds to protect them from birds.
Uses
It has been employed widely as an animal anesthetic in the laboratory setting. alpha-chloralose is a true anesthetic or an immobilizing agent with sedative-hypnotic properties has important implications. Canada geese (Branta canadensis) and blue geese (Chen caerulescens) were caught with alpha-chloralose, an oral hypnotic administered on bait. Wild turkeys (Meleagris gallopavo) were captured with alpha-chloralose, an oral anesthetic.
Uses
Chloralose is used for the control of rodents, particularly mice, and as a bird repellent and a bird narcotic.
Hazard
May cause addiction, highly toxic.
Safety Profile
Poison by ingestion, subcutaneous, and intraperitoneal routes. Questionable carcinogen with experimental tumorigenic data. When heated to decomposition it emits toxic fumes of Cl-.
Metabolic pathway
Chloralose is effectively a chloral generator which, in turn, affords trichloroethanol by metabolism. This is the narcotic agent. Sleep is induced in mice before death and therefore the compound is regarded as a humane mouse killer. It is particularly effective when a quick clearout is required but there is evidence that mice can become tolerant.
Degradation
Chloralose is hydrolysed by acid and base to glucose and chloral (2, trichloroacetaldehyde).
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α-Chloralose(15879-93-3)Related Product Information
- α-Lipoic Acid
- Diethylstilbestrol
- Tris(2-chloroethyl) phosphate
- D(+)-Glucose
- Trichlorosilane
- Chloral
- Tetrahydrofuran
- Chloral hydrate
- Trichloroisocyanuric acid
- Sucralose
- Trichloroethylene
- Furazolidone
- Trichloroacetic acid
- 6-Bromo-1-hexene
- 2,4-DIMETHYL, 1,3-DIOXALONE
- D-arabinitol
- 2-ETHOXYTETRAHYDROFURAN
- Chloroform