HARMALINE Chemical Properties

Melting point:

232-234 °C(lit.)

Boiling point:

354.4°C (rough estimate)

alpha 

±0°

Density 

1.0850 (rough estimate)

refractive index 

1.6450 (estimate)

Water Solubility 

Slightly soluble in water

solubility 

DMF: 1.4 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 0.25 mg/ml; Ethanol: 0.5 mg/ml

form 

powder

pka

4.2(at 25℃)

color 

Light orange to Yellow to Green

Merck 

14,4613

BRN 

207310

LogP

2.251 (est)

CAS DataBase Reference

304-21-2(CAS DataBase Reference)

NIST Chemistry Reference

Harmaline(304-21-2)

EPA Substance Registry System

3H-Pyrido[3,4-b]indole, 4,9-dihydro-7-methoxy-1-methyl- (304-21-2)

Safety Information

Hazard Codes 

Xn

Risk Statements 

25-20/21/22

Safety Statements 

22-24/25-36

RIDADR 

1544

WGK Germany 

3

RTECS 

UU9800000

HS Code 

2939.80.0000

HazardClass 

6.1(b)

PackingGroup 

III

Hazardous Substances Data

304-21-2(Hazardous Substances Data)

MSDS

• Language:English Provider:SigmaAldrich

HARMALINE Usage And Synthesis

Uses

CNS stimulant, antiparkinsonian agent

Uses

CNS stimulant; may act through NMDA receptors. Reversible inhibitor of MAO-A

Definition

ChEBI: A harmala alkaloid in which the harman skeleton is methoxy-substituted at C-7 and has been reduced across the 3,4 bond.

Synthesis Reference(s)

Canadian Journal of Chemistry, 37, p. 1851, 1959 DOI: 10.1139/v59-272

Purification Methods

Recrystallise harmaline from MeOH and sublime it at high vacuum. It has UV in MeOH a

HARMALINE(304-21-2)Related Product Information

• Sophoridine
• 6-Methoxyindole
• 2-METHYL-1H-PYRROLE
• HARMALINE
• 2,3-Dimethylindole
• Indole
• 2-Ethyl-1H-indole
• 3-(2-Aminoethyl)-6-methoxyindole
• 3-METHYLPYRROLE
• 3-Methylindole
• HARMALOL
• 6-Hydroxyindole
• Pyrrole
• Tryptamine
• 2-Methylindole-3-ethylamine
• Vasicine
• HARMALINE HYDROCHLORIDE,HARMALINE HCL
• 3-Ethylindole