RO-31-8220 Chemical Properties

storage temp. 

2-8°C

solubility 

DMSO:52.77(Max Conc. mg/mL);95.31(Max Conc. mM)
DMF:25.0(Max Conc. mg/mL);45.15(Max Conc. mM)
DMF:PBS (pH 7.2) (1:9):0.1(Max Conc. mg/mL);0.18(Max Conc. mM)
Ethanol:2.77(Max Conc. mg/mL);5.0(Max Conc. mM)

form 

Red solid

color 

Red

biological source

synthetic (organic)

Water Solubility 

water: 1mg/mL
DMSO: 100mg/mL

Safety Information

HS Code 

2933790090

RO-31-8220 Usage And Synthesis

Description

Ro 31-8220 mesylate is a potent PKC inhibitor, inhibits PKCα, PKCβI, PKCβII, PKCγ, PKCε and rat brain PKC with IC50 values of 5, 24, 14, 27, 24 and 23 nM, also inhibits MAPKAP -K1b, MSK1, S6K1 and GSK3β with IC50 of 3, 8, 15, 38 nM.

Uses

Ro 31-8220 Mesylate is a protein kinase C (PKC) inhibitor.

General Description

Ro 31-8220 is a bisindolylmaleimide derivative of staurosporine. Ro 31-8220 blocks MAP kinase phosphatase-1 (MKP-1) expression, induces c-Jun expression and stimulates Jun N-terminal Kinase (JNK1). It has immunosuppressive properties.

Biochem/physiol Actions

Inhibitor of GRK-5 (G protein-coupled receptor kinase); PKC (protein kinase C); MAPKAP kinase 1β and p70 S6 kinase.

in vivo

IC 50

PKC-α: 5 nM (IC₅₀); PKC-βII: 14 nM (IC₅₀); PKC-βI: 24 nM (IC₅₀); PKC-ε: 24 nM (IC₅₀); PKC-γ: 27 nM (IC₅₀); Rat Brain PKC: 23 nM (IC₅₀); MAPKAP-K1b: 3 nM (IC₅₀); MSK1: 8 nM (IC₅₀); S6K1: 15 nM (IC₅₀); GSK3β: 38 nM (IC₅₀)

storage

+4°C

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