RO-31-8220 Chemical Properties

storage temp. 

2-8°C

solubility 

DMSO:52.77(Max Conc. mg/mL);95.31(Max Conc. mM)
DMF:25.0(Max Conc. mg/mL);45.15(Max Conc. mM)
DMF:PBS (pH 7.2) (1:9):0.1(Max Conc. mg/mL);0.18(Max Conc. mM)
Ethanol:2.77(Max Conc. mg/mL);5.0(Max Conc. mM)

form 

Red solid

color 

Red

Safety Information

HS Code 

2933790090

RO-31-8220 Usage And Synthesis

Description

Ro 31-8220 mesylate is a potent PKC inhibitor, inhibits PKCα, PKCβI, PKCβII, PKCγ, PKCε and rat brain PKC with IC50 values of 5, 24, 14, 27, 24 and 23 nM, also inhibits MAPKAP -K1b, MSK1, S6K1 and GSK3β with IC50 of 3, 8, 15, 38 nM.

Uses

Ro 31-8220 Mesylate is a protein kinase C (PKC) inhibitor.

General Description

Ro 31-8220 is a bisindolylmaleimide derivative of staurosporine. Ro 31-8220 blocks MAP kinase phosphatase-1 (MKP-1) expression, induces c-Jun expression and stimulates Jun N-terminal Kinase (JNK1). It has immunosuppressive properties.

Biochem/physiol Actions

Inhibitor of GRK-5 (G protein-coupled receptor kinase); PKC (protein kinase C); MAPKAP kinase 1β and p70 S6 kinase.

storage

+4°C

RO-31-8220(138489-18-6)Related Product Information

• GO 6976
• D-ERYTHRO-SPHINGOSINE
• GO 6983
• Nintedanib
• Dasatinib
• ABT 263
• Ponatinib
• Ibrutinib
• GF109203X
• GANGLIOSIDE GD1A DISODIUM SALT
• BISINDOLYLMALEIMIDE VII
• 2,2',3,3',4,4'-hexahydroxy-1,1'-biphenyl-6,6'-dimethanol dimethyl ether
• 3,4-Di-1H-indol-3-yl-1H-pyrrole-2,5-dione
• RO-31-8220
• 1-METHYLINDOLE-3-ACETAMIDE
• RO-31-8220,RO 31-8220 METHANESULFONATE,RO 31-8220 MESYLATE
• 3-Isopropenyl-1-methyl-1H-pyrrole
• RO 31-8220 (BISINDOYLMALEIMIDINE IX)