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Vardenafil dihydrochloride

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Vardenafil dihydrochloride Basic information

Product Name:
Vardenafil dihydrochloride
Synonyms:
  • VARDENAFIL CITRATE
  • VARDANAFIL
  • VARDENAFILDIHYDROCHLORIDE(SUBJECTTOPATENTFREE)
  • 1-[[3-(1,4-Dihydro-5-methyl-4-oxo-7-propylimidazo[5,1-f][1,2,4]triazin-2-yl)-4-ethoxyphenyl]sulfonyl]-4-ethyl-piperazine dihydrochloride
  • Levitra
  • Vardenafil dihydrochloride
  • 2-[2-ethoxy-5-(4-ethylpiperazin-1-yl)sulfonyl-phenyl]-5-methyl-7-propyl-1H-imidazo[5,1-f][1,2,4]triazin-4-one dihydrochloride
  • 2-[2-ethoxy-5-(4-ethylpiperazin-1-yl)sulfonylphenyl]-5-methyl-7-propyl-1H-imidazo[5,1-f][1,2,4]triazin-4-one dihydrochloride
CAS:
224789-15-5
MF:
C23H33ClN6O4S
MW:
525.07
EINECS:
200-659-6
Product Categories:
  • 11
  • Active Pharmaceutical Ingredients
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Sulfur & Selenium Compounds
  • LEVITRA
  • 224789-15-5
Mol File:
224789-15-5.mol
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Vardenafil dihydrochloride Chemical Properties

Melting point:
214-216°C
storage temp. 
Refrigerator
solubility 
DMSO (Slightly, Heated), Methanol (Slightly)
form 
Solid
color 
White to Off-White
CAS DataBase Reference
224789-15-5(CAS DataBase Reference)
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Safety Information

Hazard Codes 
F,T
Risk Statements 
11-23/24/25-39/23/24/25
Safety Statements 
7-16-36/37-45
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Vardenafil dihydrochloride Usage And Synthesis

Chemical Properties

White to Off-White Cyrstalline Solid

Uses

erectile dysfunction, PD5 inhibitor

Uses

Vardenafil Dihydrochloride Salt is a selective phosphodiesterase type 5 (PDE5) inhibitor.

Uses

A selective phsphodiesterase type 5 (PDE5) inhibitor.

in vivo

Vardenafil dihydrochloride (0.03 mg/kg; i.v.) exhibits facilitator effects in rats with cavernous nerve injury[4].
Vardenafil dihydrochloride (0.17 mg/kg; i.v.; once daily; 7 d) protects liver against Con A–induced hepatitis, and decreases the expression of NF-??B and iNOS in hepatic tissue[5].
Vardenafil dihydrochloride (10 mg/kg; p.o.; once daily; 25 weeks) prevents the reduction of tissue cGMP levels and the increase in 3-NT generation in ZDF hearts[6].

Animal Model:Male rat (9-week-old) underwent surgery for laparotomy or bilateral cavernous nerve (CN) crush injury[4]
Dosage:0.03 mg/kg
Administration:Intravenous injection
Result:Restored normal erectile responses with a combind administration of BAY 60-4552 (0.03, 0.3 mg/kg).
Animal Model:Liver injury induced by Con A in male Swiss albino mice (20 ± 2 g)[5]
Dosage:0.17 mg/kg
Administration:Intravenous injection; once daily, for 7 days; as a pretreatment
Result:Reduced the levels of serum transaminases and alleviated Con A-induced hepatitis.
Animal Model:Male 7-week-old Zucker diabetic fatty (ZDF) rats (preserved ejection fraction, HFpEF)[6]
Dosage:10 mg/kg
Administration:Oral gavage; once daily, for 25 weeks
Result:Improved myofilament function in diabetic rat hearts.

IC 50

PDE5: 0.7 nM (IC50); PDE1: 180 nM (IC50); PDE6: 11 nM (IC50)

Vardenafil dihydrochlorideSupplier

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