(S)-1-N-Boc-2-methylpiperazine Chemical Properties

Melting point:

43.0 to 47.0 °C

Boiling point:

268.7±15.0 °C(Predicted)

Density 

0.997±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

solubility 

soluble in Methanol

form 

powder to crystal

pka

8.49±0.40(Predicted)

color 

White to Almost white

InChI

InChI=1S/C10H20N2O2/c1-8-7-11-5-6-12(8)9(13)14-10(2,3)4/h8,11H,5-7H2,1-4H3/t8-/m0/s1

InChIKey

DATRVIMZZZVHMP-QMMMGPOBSA-N

SMILES

N1(C(OC(C)(C)C)=O)CCNC[C@@H]1C

CAS DataBase Reference

169447-70-5(CAS DataBase Reference)

Safety Information

RIDADR 

UN3077

HS Code 

2933599590

(S)-1-N-Boc-2-methylpiperazine Usage And Synthesis

Uses

(S)-1-N-Boc-2-methylpiperazine is used in the preparation of pyrazolo[3,4-b]pyridine dual pharmacophores as PDE4-muscarinic antagonists.

Synthesis

A solution of (S)-2-methyl piperazine (2 g, 20 mmol) in THF (200 ml_) was mixed with nBuLi (25 ml, 1.6 M in hexanes, 40 mmol) at rt. The solution was stirred for 30 minutes before TBDMSCI (3.04 g, 20 mmol) was added. The mixture was stirred for 1 hour and then (Boc)2O (5.2 g, 24 mmol) was added to the solution. After 1 hour, the solution was diluted with H2O (50 ml). The organic layer was separated, washed with brine (50 mL), dried over Na2SO4, and concentrated EPO under vacuum. Finally, (S)-1-N-Boc-2-methylpiperazine was obtained after purification.

(S)-1-N-Boc-2-methylpiperazine(169447-70-5)Related Product Information

• tert-Butyl peroxybenzoate
• 1-Methylpiperazine
• N-Methyl-2-pyrrolidone
• 1,2-Dimethylhydrazine Dihydrochloride
• N-Methylolacrylamide
• 2-Methylpiperazine
• Diisobutyl phthalate
• 1-BENZHYDRYLPIPERAZINE
• Butylparaben
• 1-Methylimidazole
• N-Methyldiethanolamine
• N-Methylacetamide
• Isobutyl chloroformate
• (S)-1-Boc-2-isopropylpiperazine
• (S)-2-THIOCARBAMOYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
• D-1-N-Boc-prolinamide
• (S)-(+)-N-TBOC-2-METHYLPIPERIDINE
• (S)-tert-butyl 4-aMinoazepane-1-carboxylate